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Displaying record number 62894

HXB2 Location Pol(838-847) Pol Epitope Map
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STTVKAACWW

`{tNFT}SaaVKAACWW`		replicative capacity is not abrogated
`{rNFT}SaaVKAACWW`		replicative capacity is not abrogated
`{pNFT}SaaVKAACWW`		replicative capacity reduced
`{tNFT}STTVKAACWW`		replicative capacity is not abrogated
`{rNFT}STTVKAACWW`		replicative capacity reduced
`{pNFT}STTVKAACWW`		replicative capacity is not abrogated

Epitope Name SW10

Species (MHC/HLA) human

Variant Details

Showing all: 6 variant(s).

Variant ID.	`5073`
Epitope Seq.	`{SNFT}STTVKAACWW`
Variant Seq.	`{tNFT}SaaVKAACWW`
Mutations	T/A T/A S/T
Epitope Location	T2A T3A S-4T
HXB2 Location	T839A T840A S834T
Mutation Type	RCOK: replicative capacity is not abrogated
Epitope Subtype	C
Variant Subtype	C
Method	Other, Relative replication capacity assay
Note	The introduction of S119T (integrase protein position) onto either wild-type NL4-3 subtype B virus encoding well-defined epitope {SNFT}STTVKAACWW (see CTL variant record #5076) or recombinant NL4-3 virus with subtype C RT-integrase encoding analogous {SNFT}SaaVKAACWW had no effect on replicative capacity. Residue 119 is also located within epitope HTDNGSNF.

Variant ID.	`5074`
Epitope Seq.	`{SNFT}STTVKAACWW`
Variant Seq.	`{rNFT}SaaVKAACWW`
Mutations	T/A T/A S/R
Epitope Location	T2A T3A S-4R
HXB2 Location	T839A T840A S834R
Mutation Type	RCOK: replicative capacity is not abrogated
Epitope Subtype	C
Variant Subtype	C
Method	Other, Relative replication capacity assay
Note	The introduction of S119R (integrase protein position) onto subtype B wild-type NL4-3 virus carrying best-defined epitope {SNFT}STTVKAACWW did not produce detectable cultured virus (see CTL variant record #5077), but did not affect replicative capacity of NL4-3 recombinant virus encoding subtype C RT-integrase carrying the analogous sequence {SNFT}SaaVKAACWW. Residue 119 is also located within epitope HTDNGSNF.

Variant ID.	`5075`
Epitope Seq.	`{SNFT}STTVKAACWW`
Variant Seq.	`{pNFT}SaaVKAACWW`
Mutations	T/A T/A S/P
Epitope Location	T2A T3A S-4P
HXB2 Location	T839A T840A S834P
Mutation Type	RCR: replicative capacity reduced
Epitope Subtype	C
Variant Subtype	C
Method	Other, Relative replication capacity assay
Note	The introduction of S119P (integrase protein position) onto subtype B wild-type NL4-3 virus carrying best-defined epitope {SNFT}STTVKAACWW did not affect replicative capacity (see CTL variant record #5078), but did not produce detectable cultured virus on a NL4-3 recombinant virus encoding subtype C RT-integrase carrying the analogous sequence {SNFT}SaaVKAACWW. Residue 119 is also located within epitope HTDNGSNF.

Variant ID.	`5076`
Epitope Seq.	`{SNFT}STTVKAACWW`
Variant Seq.	`{tNFT}STTVKAACWW`
Mutations	S/T
Epitope Location	S-4T
HXB2 Location	S834T
Mutation Type	RCOK: replicative capacity is not abrogated
Epitope Subtype	B
Variant Subtype	B
Method	Other, Relative replication capacity assay
Note	The introduction of S119T (integrase protein position) onto either wild-type NL4-3 subtype B virus encoding well-defined epitope {SNFT}STTVKAACWW or recombinant NL4-3 virus with subtype C RT-integrase encoding analogous {SNFT}SaaVKAACWW (see CTL variant record #5073) had no effect on replicative capacity. Residue 119 is also located within epitope HTDNGSNF.

Variant ID.	`5077`
Epitope Seq.	`{SNFT}STTVKAACWW`
Variant Seq.	`{rNFT}STTVKAACWW`
Mutations	S/R
Epitope Location	S-4R
HXB2 Location	S834R
Mutation Type	RCR: replicative capacity reduced
Epitope Subtype	B
Variant Subtype	B
Method	Other, Relative replication capacity assay
Note	The introduction of S119R (integrase protein position) onto subtype B wild-type NL4-3 virus carrying best-defined epitope {SNFT}STTVKAACWW did not produce detectable cultured virus, but did not affect replicative capacity of NL4-3 recombinant virus encoding subtype C RT-integrase carrying the analogous sequence {SNFT}SaaKAACWW (see CTL variant record #5074). Residue 119 is also located within epitope HTDNGSNF.

Variant ID.	`5078`
Epitope Seq.	`{SNFT}STTVKAACWW`
Variant Seq.	`{pNFT}STTVKAACWW`
Mutations	S/P
Epitope Location	S-4P
HXB2 Location	S834P
Mutation Type	RCOK: replicative capacity is not abrogated
Epitope Subtype	B
Variant Subtype	B
Method	Other, Relative replication capacity assay
Note	The introduction of S119P (integrase protein position) onto subtype B wild-type NL4-3 virus carrying best-defined epitope {SNFT}STTVKAACWW did not affect replicative capacity, but did not produce detectable cultured virus on a NL4-3 recombinant virus encoding subtype C RT-integrase carrying the analogous sequence {SNFT}SaaVKAACWW (see CTL variant record #5075). Residue 119 is also located within epitope HTDNGSNF.

References

Ojwach2021 Doty B. A. Ojwach, Paradise Madlala, Michelle Gordon, Thumbi Ndung'u, and Jaclyn K. Mann. Vulnerable targets in HIV-1 Pol for attenuation-based vaccine design. Virology, 554:1-8 doi, Feb 2021. PubMed ID: 33316731 Show all entries for this paper.