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Found 1 matching record:

Displaying record number 62894

HXB2 Location  Pol(838-847)   Pol Epitope Map
View variants at this location
Epitope STTVKAACWW   Epitope Alignment
Variants
{tNFT}SaaVKAACWW   replicative capacity is not abrogated
{rNFT}SaaVKAACWW   replicative capacity is not abrogated
{pNFT}SaaVKAACWW   replicative capacity reduced
{tNFT}STTVKAACWW   replicative capacity is not abrogated
{rNFT}STTVKAACWW   replicative capacity reduced
{pNFT}STTVKAACWW   replicative capacity is not abrogated
Epitope Name SW10
Species (MHC/HLA human

Variant Details

Showing all: 6 variant(s).


Variant ID.  5073
Epitope Seq.  {SNFT}STTVKAACWW
Variant Seq.  {tNFT}SaaVKAACWW
Mutations T/A T/A S/T
Epitope Location T2A T3A S-4T
HXB2 Location T839A T840A S834T
Mutation Type RCOK: replicative capacity is not abrogated
Epitope Subtype C
Variant Subtype C
Method Other, Relative replication capacity assay
Note The introduction of S119T (integrase protein position) onto either wild-type NL4-3 subtype B virus encoding well-defined epitope {SNFT}STTVKAACWW (see CTL variant record #5076) or recombinant NL4-3 virus with subtype C RT-integrase encoding analogous {SNFT}SaaVKAACWW had no effect on replicative capacity. Residue 119 is also located within epitope HTDNGSNF.


Variant ID.  5074
Epitope Seq.  {SNFT}STTVKAACWW
Variant Seq.  {rNFT}SaaVKAACWW
Mutations T/A T/A S/R
Epitope Location T2A T3A S-4R
HXB2 Location T839A T840A S834R
Mutation Type RCOK: replicative capacity is not abrogated
Epitope Subtype C
Variant Subtype C
Method Other, Relative replication capacity assay
Note The introduction of S119R (integrase protein position) onto subtype B wild-type NL4-3 virus carrying best-defined epitope {SNFT}STTVKAACWW did not produce detectable cultured virus (see CTL variant record #5077), but did not affect replicative capacity of NL4-3 recombinant virus encoding subtype C RT-integrase carrying the analogous sequence {SNFT}SaaVKAACWW. Residue 119 is also located within epitope HTDNGSNF.


Variant ID.  5075
Epitope Seq.  {SNFT}STTVKAACWW
Variant Seq.  {pNFT}SaaVKAACWW
Mutations T/A T/A S/P
Epitope Location T2A T3A S-4P
HXB2 Location T839A T840A S834P
Mutation Type RCR: replicative capacity reduced
Epitope Subtype C
Variant Subtype C
Method Other, Relative replication capacity assay
Note The introduction of S119P (integrase protein position) onto subtype B wild-type NL4-3 virus carrying best-defined epitope {SNFT}STTVKAACWW did not affect replicative capacity (see CTL variant record #5078), but did not produce detectable cultured virus on a NL4-3 recombinant virus encoding subtype C RT-integrase carrying the analogous sequence {SNFT}SaaVKAACWW. Residue 119 is also located within epitope HTDNGSNF.


Variant ID.  5076
Epitope Seq.  {SNFT}STTVKAACWW
Variant Seq.  {tNFT}STTVKAACWW
Mutations S/T
Epitope Location S-4T
HXB2 Location S834T
Mutation Type RCOK: replicative capacity is not abrogated
Epitope Subtype B
Variant Subtype B
Method Other, Relative replication capacity assay
Note The introduction of S119T (integrase protein position) onto either wild-type NL4-3 subtype B virus encoding well-defined epitope {SNFT}STTVKAACWW or recombinant NL4-3 virus with subtype C RT-integrase encoding analogous {SNFT}SaaVKAACWW (see CTL variant record #5073) had no effect on replicative capacity. Residue 119 is also located within epitope HTDNGSNF.


Variant ID.  5077
Epitope Seq.  {SNFT}STTVKAACWW
Variant Seq.  {rNFT}STTVKAACWW
Mutations S/R
Epitope Location S-4R
HXB2 Location S834R
Mutation Type RCR: replicative capacity reduced
Epitope Subtype B
Variant Subtype B
Method Other, Relative replication capacity assay
Note The introduction of S119R (integrase protein position) onto subtype B wild-type NL4-3 virus carrying best-defined epitope {SNFT}STTVKAACWW did not produce detectable cultured virus, but did not affect replicative capacity of NL4-3 recombinant virus encoding subtype C RT-integrase carrying the analogous sequence {SNFT}SaaKAACWW (see CTL variant record #5074). Residue 119 is also located within epitope HTDNGSNF.


Variant ID.  5078
Epitope Seq.  {SNFT}STTVKAACWW
Variant Seq.  {pNFT}STTVKAACWW
Mutations S/P
Epitope Location S-4P
HXB2 Location S834P
Mutation Type RCOK: replicative capacity is not abrogated
Epitope Subtype B
Variant Subtype B
Method Other, Relative replication capacity assay
Note The introduction of S119P (integrase protein position) onto subtype B wild-type NL4-3 virus carrying best-defined epitope {SNFT}STTVKAACWW did not affect replicative capacity, but did not produce detectable cultured virus on a NL4-3 recombinant virus encoding subtype C RT-integrase carrying the analogous sequence {SNFT}SaaVKAACWW (see CTL variant record #5075). Residue 119 is also located within epitope HTDNGSNF.

References

Ojwach2021 Doty B. A. Ojwach, Paradise Madlala, Michelle Gordon, Thumbi Ndung'u, and Jaclyn K. Mann. Vulnerable targets in HIV-1 Pol for attenuation-based vaccine design. Virology, 554:1-8 doi, Feb 2021. PubMed ID: 33316731 Show all entries for this paper.


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