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Displaying record number 62866

HXB2 Location  gp160(786-794)   gp160 Epitope Map
View variants at this location
Epitope GRRGWEILK   Epitope Alignment
Variants
GhRGWEILK   escape documented in this paper; inferred escape; observed variant
GlRGWEILK   escape documented in this paper; inferred escape; observed variant
GlRGWEILK{Y-W}   escape documented in this paper; inferred escape; observed variant
GhRGWkILK   escape documented in this paper; inferred escape; observed variant
GRRGrEILK   escape documented in this paper; inferred escape; observed variant
GRRGWgILK   escape documented in this paper; inferred escape; observed variant
GRRGWElLK   escape documented in this paper; inferred escape; observed variant
GRRGWkILK   escape documented in this paper; inferred escape; observed variant
GRRGWEtLK   escape documented in this paper; inferred escape; observed variant
GRRGWEsLK   escape documented in this paper; inferred escape; observed variant
GRRGWEvLK   escape documented in this paper; inferred escape; observed variant
GRRGWEnLK   escape documented in this paper; inferred escape; observed variant
GRRGWdILK   escape documented in this paper; inferred escape; observed variant
GRRGgEILK   escape documented in this paper; inferred escape; observed variant
Epitope Name GK9
Species (MHC/HLA humanized mouse

Variant Details

Showing all: 14 variant(s).


Variant ID.  4983
Epitope Seq.  GRRGWEILK
Variant Seq.  GhRGWEILK
Mutations R/H
Epitope Location R2H
HXB2 Location R787H
Mutation Type E: escape documented in this paper
IE: inferred escape
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study
Note At 12 weeks post HIV-1JR-CSF-infection, variant GhRGWEILK was observed in 2/3 PBS control, 4/7 GFP control and 3/7 Gag-immunized mice with a frequency per mouse of 11-78%.


Variant ID.  4984
Epitope Seq.  GRRGWEILK
Variant Seq.  GlRGWEILK
Mutations R/L
Epitope Location R2L
HXB2 Location R787L
Mutation Type E: escape documented in this paper
IE: inferred escape
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study
Note At 12 weeks post HIV-1JR-CSF-infection, variant GlRGWEILK was observed in 1/3 PBS control, 0/7 GFP control and 1/7 Gag-immunized mice with a frequency per mouse of 16-35%.


Variant ID.  4985
Epitope Seq.  GRRGWEILK{YWW}
Variant Seq.  GlRGWEILK{Y-W}
Mutations W/- R/L
Epitope Location W+2- R2L
HXB2 Location W796- R787L
Mutation Type E: escape documented in this paper
IE: inferred escape
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study
Note At 12 weeks post HIV-1JR-CSF-infection, variant GlRGWEILK{Y-W} was observed in 6% of the sequencing reads in 1/7 Gag-immunized mice but not in any of the 3 PBS control or 7 GFP control mice.


Variant ID.  4986
Epitope Seq.  GRRGWEILK
Variant Seq.  GhRGWkILK
Mutations R/H E/K
Epitope Location R2H E6K
HXB2 Location R787H E791K
Mutation Type E: escape documented in this paper
IE: inferred escape
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study
Note At 12 weeks post HIV-1JR-CSF-infection, variant GhRGWkILK was observed in 5% of the sequencing reads in 1/7 GFP control mice but not in any of the 3 PBS control or 7 Gag-immunized mice.


Variant ID.  4987
Epitope Seq.  GRRGWEILK
Variant Seq.  GRRGrEILK
Mutations W/R
Epitope Location W5R
HXB2 Location W790R
Mutation Type E: escape documented in this paper
IE: inferred escape
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study
Note At 12 weeks post HIV-1JR-CSF-infection, variant GRRGrEILK was observed in 1/3 PBS control, 3/7 GFP control and 1/7 Gag-immunized mice with a frequency per mouse of 6-40%.


Variant ID.  4988
Epitope Seq.  GRRGWEILK
Variant Seq.  GRRGWgILK
Mutations E/G
Epitope Location E6G
HXB2 Location E791G
Mutation Type E: escape documented in this paper
IE: inferred escape
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study
Note At 12 weeks post HIV-1JR-CSF-infection, variant GRRGWgILK was observed in 1/3 PBS control, 3/7 GFP control and 3/7 Gag-immunized mice with a frequency per mouse of 6-74%.


Variant ID.  4989
Epitope Seq.  GRRGWEILK
Variant Seq.  GRRGWElLK
Mutations I/L
Epitope Location I7L
HXB2 Location I792L
Mutation Type E: escape documented in this paper
IE: inferred escape
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study
Note At 12 weeks post HIV-1JR-CSF-infection, variant GRRGWElLK was observed in 1/3 PBS control, 1/7 GFP control and 1/7 Gag-immunized mice with a frequency per mouse of 5-12%.


Variant ID.  4990
Epitope Seq.  GRRGWEILK
Variant Seq.  GRRGWkILK
Mutations E/K
Epitope Location E6K
HXB2 Location E791K
Mutation Type E: escape documented in this paper
IE: inferred escape
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study
Note At 12 weeks post HIV-1JR-CSF-infection, variant GRRGWkILK was observed in 1/3 PBS control, 2/7 GFP control and 3/7 Gag-immunized mice with a frequency per mouse of 6-33%.


Variant ID.  4991
Epitope Seq.  GRRGWEILK
Variant Seq.  GRRGWEtLK
Mutations I/T
Epitope Location I7T
HXB2 Location I792T
Mutation Type E: escape documented in this paper
IE: inferred escape
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study
Note At 12 weeks post HIV-1JR-CSF-infection, variant GRRGWEtLK was observed in 1/3 PBS control, 4/7 GFP control and 4/7 Gag-immunized mice with a frequency per mouse of 7-51%.


Variant ID.  4992
Epitope Seq.  GRRGWEILK
Variant Seq.  GRRGWEsLK
Mutations I/S
Epitope Location I7S
HXB2 Location I792S
Mutation Type E: escape documented in this paper
IE: inferred escape
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study
Note At 12 weeks post HIV-1JR-CSF-infection, variant GRRGWEsLK was observed in 6% of the sequencing reads in 1/7 GFP control mice but not in any of the 3 PBS control or 7 Gag-immunized mice.


Variant ID.  4993
Epitope Seq.  GRRGWEILK
Variant Seq.  GRRGWEvLK
Mutations I/V
Epitope Location I7V
HXB2 Location I792V
Mutation Type E: escape documented in this paper
IE: inferred escape
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study
Note At 12 weeks post HIV-1JR-CSF-infection, variant GRRGWEvLK was observed in 0/3 PBS control, 4/7 GFP control and 1/7 Gag-immunized mice with a frequency per mouse of 8-53%.


Variant ID.  4994
Epitope Seq.  GRRGWEILK
Variant Seq.  GRRGWEnLK
Mutations I/N
Epitope Location I7N
HXB2 Location I792N
Mutation Type E: escape documented in this paper
IE: inferred escape
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study
Note At 12 weeks post HIV-1JR-CSF-infection, variant GRRGWEnLK was observed in 28% of the sequencing reads in 1/7 Gag-immunized mice but not in any of the 3 PBS control or 7 GFP control mice.


Variant ID.  4995
Epitope Seq.  GRRGWEILK
Variant Seq.  GRRGWdILK
Mutations E/D
Epitope Location E6D
HXB2 Location E791D
Mutation Type E: escape documented in this paper
IE: inferred escape
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study
Note At 12 weeks post HIV-1JR-CSF-infection, variant GRRGWdILK was observed in 11% of the sequencing reads in 1/7 Gag-immunized mice but not in any of the 3 PBS control or 7 GFP control mice.


Variant ID.  4996
Epitope Seq.  GRRGWEILK
Variant Seq.  GRRGgEILK
Mutations W/G
Epitope Location W5G
HXB2 Location W790G
Mutation Type E: escape documented in this paper
IE: inferred escape
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study
Note At 12 weeks post HIV-1JR-CSF-infection, variant GRRGgEILK was observed in 39% of the sequencing reads in 1/7 Gag-immunized mice but not in any of the 3 PBS control or 7 GFP control mice.

References

Claiborne2019 Daniel T. Claiborne, Timothy E. Dudek, Colby R. Maldini, Karen A. Power, Musie Ghebremichael, Edward Seung, Elizabeth F. Mellors, Vladimir D. Vrbanac, Katharine Krupp, Abigail Bisesi, Andrew M. Tager, David M. Knipe, Christian L. Boutwell, and Todd M. Allen. Immunization of BLT Humanized Mice Redirects T Cell Responses to Gag and Reduces Acute HIV-1 Viremia. J. Virol., 93(20), 15 Oct 2019. PubMed ID: 31375576. Show all entries for this paper.


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