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Found 1 matching record:

Displaying record number 62860

HXB2 Location  gp160(383-391)   gp160 Epitope Map
View variants at this location
Epitope FYCNSTQLF   Epitope Alignment
Variants
FYCdSTQLF   observed variant
FYCsSTQLF   observed variant
FYCNSTQLF{NSi}   observed variant
Epitope Name FF9
Species (MHC/HLA humanized mouse(A*24)

Variant Details

Showing all: 3 variant(s).


Variant ID.  4956
Epitope Seq.  FYCNSTQLF
Variant Seq.  FYCdSTQLF
Mutations N/D
Epitope Location N4D
HXB2 Location N386D
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study
Note At 12 weeks post HIV-1JR-CSF-infection, variant FYCdSTQLF was observed in 2/4 Gag-immunized and 3/4 GFP control mice with a frequency per mouse of 8-29%.


Variant ID.  4957
Epitope Seq.  FYCNSTQLF
Variant Seq.  FYCsSTQLF
Mutations N/S
Epitope Location N4S
HXB2 Location N386S
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note At 12 weeks post HIV-1JR-CSF-infection, variant FYCsSTQLF was observed in 29% of sequencing reads in 1/4 GFP control mice and 0/4 Gag-immunized mice.


Variant ID.  4958
Epitope Seq.  FYCNSTQLF{NST}
Variant Seq.  FYCNSTQLF{NSi}
Mutations T/I
Epitope Location T+3I
HXB2 Location T394I
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study
Note At 12 weeks post HIV-1JR-CSF-infection, variant FYCNSTQLF{NSi} was observed in 10% of sequencing reads in 1/4 GFP control mice and 0/4 Gag-immunized mice.

References

Claiborne2019 Daniel T. Claiborne, Timothy E. Dudek, Colby R. Maldini, Karen A. Power, Musie Ghebremichael, Edward Seung, Elizabeth F. Mellors, Vladimir D. Vrbanac, Katharine Krupp, Abigail Bisesi, Andrew M. Tager, David M. Knipe, Christian L. Boutwell, and Todd M. Allen. Immunization of BLT Humanized Mice Redirects T Cell Responses to Gag and Reduces Acute HIV-1 Viremia. J. Virol., 93(20), 15 Oct 2019. PubMed ID: 31375576. Show all entries for this paper.


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