HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | gp160(383-391) | gp160 Epitope Map
View variants at this location |
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| Epitope |
FYCNSTQLF
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Epitope Alignment | ||||||||||
| Variants |
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| Epitope Name | FF9 | |||||||||||
| Species (MHC/HLA) | humanized mouse(A*24) | |||||||||||
Showing all: 3 variant(s).
| Variant ID. | 4956 |
|---|---|
| Epitope Seq. | FYCNSTQLF |
| Variant Seq. | FYCdSTQLF |
| Mutations | N/D |
| Epitope Location | N4D |
| HXB2 Location | N386D |
| Mutation Type | OV: observed variant |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Longitudinal study |
| Note | At 12 weeks post HIV-1JR-CSF-infection, variant FYCdSTQLF was observed in 2/4 Gag-immunized and 3/4 GFP control mice with a frequency per mouse of 8-29%. |
| Variant ID. | 4957 |
|---|---|
| Epitope Seq. | FYCNSTQLF |
| Variant Seq. | FYCsSTQLF |
| Mutations | N/S |
| Epitope Location | N4S |
| HXB2 Location | N386S |
| Mutation Type | OV: observed variant |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Sequence |
| Note | At 12 weeks post HIV-1JR-CSF-infection, variant FYCsSTQLF was observed in 29% of sequencing reads in 1/4 GFP control mice and 0/4 Gag-immunized mice. |
| Variant ID. | 4958 |
|---|---|
| Epitope Seq. | FYCNSTQLF{NST} |
| Variant Seq. | FYCNSTQLF{NSi} |
| Mutations | T/I |
| Epitope Location | T+3I |
| HXB2 Location | T394I |
| Mutation Type | OV: observed variant |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Longitudinal study |
| Note | At 12 weeks post HIV-1JR-CSF-infection, variant FYCNSTQLF{NSi} was observed in 10% of sequencing reads in 1/4 GFP control mice and 0/4 Gag-immunized mice. |
Claiborne2019 Daniel T. Claiborne, Timothy E. Dudek, Colby R. Maldini, Karen A. Power, Musie Ghebremichael, Edward Seung, Elizabeth F. Mellors, Vladimir D. Vrbanac, Katharine Krupp, Abigail Bisesi, Andrew M. Tager, David M. Knipe, Christian L. Boutwell, and Todd M. Allen. Immunization of BLT Humanized Mice Redirects T Cell Responses to Gag and Reduces Acute HIV-1 Viremia. J. Virol., 93(20), 15 Oct 2019. PubMed ID: 31375576. Show all entries for this paper.