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Displaying record number 62858

HXB2 Location  Gag(119-128)   Gag Epitope Map
View variants at this location
Epitope AADTGNSSQV   Epitope Alignment
Variants
AAnTGNSSQV   escape documented in this paper; inferred escape; observed variant
AAgTGNSSQV   escape documented in this paper; inferred escape; observed variant
AADTrNSSQV   escape documented in this paper; inferred escape; observed variant
AADiGNSSQV   escape documented in this paper; inferred escape; observed variant
AADTGNnSQV   escape documented in this paper; inferred escape; observed variant
AADTGNSSQg   escape documented in this paper; inferred escape; observed variant
AADTGNSrQV   escape documented in this paper; inferred escape; observed variant
AADTGNSrQi   escape documented in this paper; inferred escape; observed variant
AADTGNSSkV   escape documented in this paper; inferred escape; observed variant
Epitope Name AV10
Species (MHC/HLA humanized mouse

Variant Details

Showing all: 9 variant(s).


Variant ID.  4940
Epitope Seq.  AADTGNSSQV
Variant Seq.  AAnTGNSSQV
Mutations D/N
Epitope Location D3N
HXB2 Location D121N
Mutation Type E: escape documented in this paper
IE: inferred escape
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study
Note At 12 weeks post HIV-1JR-CSF-infection, variant AAnTGNSSQV was observed in 2/4 each of Gag-immunized and GFP control mice with a frequency per mouse of 18-27%.


Variant ID.  4941
Epitope Seq.  AADTGNSSQV
Variant Seq.  AAgTGNSSQV
Mutations D/G
Epitope Location D3G
HXB2 Location D121G
Mutation Type E: escape documented in this paper
IE: inferred escape
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study
Note At 12 weeks post HIV-1JR-CSF-infection, variant AAgTGNSSQV was observed in 7% of the sequencing reads in 1/4 Gag-immunized mice and in 0/4 GFP control mice.


Variant ID.  4942
Epitope Seq.  AADTGNSSQV
Variant Seq.  AADTrNSSQV
Mutations G/R
Epitope Location G5R
HXB2 Location G123R
Mutation Type E: escape documented in this paper
IE: inferred escape
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study
Note At 12 weeks post HIV-1JR-CSF-infection, variant AADTrNSSQV was observed in 4/4 Gag-immunized and 2/4 GFP control mice with a frequency per mouse of 6-77%.


Variant ID.  4943
Epitope Seq.  AADTGNSSQV
Variant Seq.  AADiGNSSQV
Mutations T/I
Epitope Location T4I
HXB2 Location T122I
Mutation Type E: escape documented in this paper
IE: inferred escape
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study
Note At 12 weeks post HIV-1JR-CSF-infection, variant AADiGNSSQV was observed in 1% of the sequencing reads in 1/4 GFP control mice and in 0/4 Gag-immunized mice.


Variant ID.  4944
Epitope Seq.  AADTGNSSQV
Variant Seq.  AADTGNnSQV
Mutations S/N
Epitope Location S7N
HXB2 Location S125N
Mutation Type E: escape documented in this paper
IE: inferred escape
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study
Note At 12 weeks post HIV-1JR-CSF-infection, variant AADTGNnSQV was observed in 1/4 each of Gag-immunized and GFP control mice with a frequency per mouse of 5-15%.


Variant ID.  4945
Epitope Seq.  AADTGNSSQV
Variant Seq.  AADTGNSSQg
Mutations V/G
Epitope Location V10G
HXB2 Location V128G
Mutation Type E: escape documented in this paper
IE: inferred escape
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study
Note At 12 weeks post HIV-1JR-CSF-infection, variant AADTGNSSQg was observed in 24% of the sequencing reads in 1/4 Gag-immunized mice and in 0/4 GFP control mice.


Variant ID.  4946
Epitope Seq.  AADTGNSSQV
Variant Seq.  AADTGNSrQV
Mutations S/R
Epitope Location S8R
HXB2 Location S126R
Mutation Type E: escape documented in this paper
IE: inferred escape
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study
Note At 12 weeks post HIV-1JR-CSF-infection, variant AADTGNSrQV was observed in 2/4 each of Gag-immunized and GFP control mice with a frequency per mouse of 1-14%.


Variant ID.  4947
Epitope Seq.  AADTGNSSQV
Variant Seq.  AADTGNSrQi
Mutations V/I S/R
Epitope Location V10I S8R
HXB2 Location V128I S126R
Mutation Type E: escape documented in this paper
IE: inferred escape
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study
Note At 12 weeks post HIV-1JR-CSF-infection, variant AADTGNSrQi was observed in 52% of the sequencing reads in 1/4 GFP control mice and in 0/4 Gag-immunized mice.


Variant ID.  4948
Epitope Seq.  AADTGNSSQV
Variant Seq.  AADTGNSSkV
Mutations Q/K
Epitope Location Q9K
HXB2 Location Q127K
Mutation Type E: escape documented in this paper
IE: inferred escape
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study
Note At 12 weeks post HIV-1JR-CSF-infection, variant AADTGNSSkV was observed in 7% of the sequencing reads in 1/4 Gag-immunized mice and in 0/4 GFP control mice.

References

Claiborne2019 Daniel T. Claiborne, Timothy E. Dudek, Colby R. Maldini, Karen A. Power, Musie Ghebremichael, Edward Seung, Elizabeth F. Mellors, Vladimir D. Vrbanac, Katharine Krupp, Abigail Bisesi, Andrew M. Tager, David M. Knipe, Christian L. Boutwell, and Todd M. Allen. Immunization of BLT Humanized Mice Redirects T Cell Responses to Gag and Reduces Acute HIV-1 Viremia. J. Virol., 93(20), 15 Oct 2019. PubMed ID: 31375576. Show all entries for this paper.


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