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Found 1 matching record:

Displaying record number 62816

HXB2 Location  Gag(294-304)   Gag Epitope Map
View variants at this location
Epitope RDYVDRFFKTL   Epitope Alignment
Variants
RDYVDRFyKTL   observed variant
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  4933
Epitope Seq.  RDYVDRFFKTL
Variant Seq.  RDYVDRFyKTL
Mutations F/Y
Epitope Location F8Y
HXB2 Location F301Y
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Other, Relative replication capacity assay
Note After mutagenesis and passaging through human T cells, 77 single nucleotide mutations were observed in epitope RDYVDRFFKTL (known to bind to A2402) & variant RDYVDRFyKTL (known to bind to B4402) with a log transformation of mean fitness score, relative to NL4-3, of -0.7271.

References

Du2017 Yushen Du, Tian-Hao Zhang, Lei Dai, Xiaojuan Zheng, Aleksandr M. Gorin, John Oishi, Ting-Ting Wu, Janice M. Yoshizawa, Xinmin Li, Otto O. Yang, Otoniel Martinez-Maza, Roger Detels, and Ren Sun. Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes. mBio, 8(6), 28 Nov 2017. PubMed ID: 29184023. Show all entries for this paper.


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