HIV molecular immunology database
Found 1 matching record:
|HXB2 Location||Gag(294-304)|| Gag Epitope Map
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Showing all: 1 variant(s).
|Mutation Type||OV: observed variant|
|Method||Other, Relative replication capacity assay|
|Note||After mutagenesis and passaging through human T cells, 77 single nucleotide mutations were observed in epitope RDYVDRFFKTL (known to bind to A2402) & variant RDYVDRFyKTL (known to bind to B4402) with a log transformation of mean fitness score, relative to NL4-3, of -0.7271.|
Du2017 Yushen Du, Tian-Hao Zhang, Lei Dai, Xiaojuan Zheng, Aleksandr M. Gorin, John Oishi, Ting-Ting Wu, Janice M. Yoshizawa, Xinmin Li, Otto O. Yang, Otoniel Martinez-Maza, Roger Detels, and Ren Sun. Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes. mBio, 8(6), 28 Nov 2017. PubMed ID: 29184023. Show all entries for this paper.