HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(263-272) | Gag Epitope Map
View variants at this location |
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| Epitope |
KRWIILGLNK
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Epitope Alignment | ||||||||||
| Variants |
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| Epitope Name | KK10 | |||||||||||
| Species (MHC/HLA) | human(B27) | |||||||||||
Showing all: 3 variant(s).
| Variant ID. | 4926 |
|---|---|
| Epitope Seq. | KRWIILGLNK |
| Variant Seq. | KRWIImGLNK |
| Mutations | L/M |
| Epitope Location | L6M |
| HXB2 Location | L268M |
| Mutation Type | OV: observed variant |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Longitudinal study, Other, Relative replication capacity assay |
| Note | KRWIImGLNK was only observed in PBMCs from treatment-naive LTNP G2P2 sampled at second time point (7/20/1988). Per author communication, G2P2 is also identified as subject 41811 in MACS. |
| Variant ID. | 4927 |
|---|---|
| Epitope Seq. | KRWIILGLNK |
| Variant Seq. | KRWIIiGLhK |
| Mutations | L/I N/H |
| Epitope Location | L6I N9H |
| HXB2 Location | L268I N271H |
| Mutation Type | OV: observed variant |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Longitudinal study, Other, Relative replication capacity assay |
| Note | KRWIIiGLhK was only observed in PBMCs from treatment-naive LTNP G2P2 sampled at second time point (7/20/1988). Per author communication, G2P2 is also identified as subject 41811 in MACS. |
| Variant ID. | 4930 |
|---|---|
| Epitope Seq. | KRWIILGLNK |
| Variant Seq. | rRWIqLGLqK |
| Mutations | K/R I/Q N/Q |
| Epitope Location | K1R I5Q N9Q |
| HXB2 Location | K263R I267Q N271Q |
| Mutation Type | OV: observed variant |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Other, Relative replication capacity assay |
| Note | After mutagenesis and passaging through human T cells, 60 single nucleotide mutations were observed in epitope KRWIILGLNK (known to bind to B2705) & variant rRWIqLGLqK (known to bind to B2703) with a log transformation of mean fitness score, relative to NL4-3, of -0.5469. |
Du2017 Yushen Du, Tian-Hao Zhang, Lei Dai, Xiaojuan Zheng, Aleksandr M. Gorin, John Oishi, Ting-Ting Wu, Janice M. Yoshizawa, Xinmin Li, Otto O. Yang, Otoniel Martinez-Maza, Roger Detels, and Ren Sun. Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes. mBio, 8(6), 28 Nov 2017. PubMed ID: 29184023. Show all entries for this paper.