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Displaying record number 62809

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KRWIImGLNK   observed variant
KRWIIiGLhK   observed variant
rRWIqLGLqK   observed variant
Epitope Name KK10
Species (MHC/HLA human(B27)

Variant Details

Showing all: 3 variant(s).


Variant ID.  4926
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIImGLNK
Mutations L/M
Epitope Location L6M
HXB2 Location L268M
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study, Other, Relative replication capacity assay
Note KRWIImGLNK was only observed in PBMCs from treatment-naive LTNP G2P2 sampled at second time point (7/20/1988). Per author communication, G2P2 is also identified as subject 41811 in MACS.


Variant ID.  4927
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIIiGLhK
Mutations L/I N/H
Epitope Location L6I N9H
HXB2 Location L268I N271H
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study, Other, Relative replication capacity assay
Note KRWIIiGLhK was only observed in PBMCs from treatment-naive LTNP G2P2 sampled at second time point (7/20/1988). Per author communication, G2P2 is also identified as subject 41811 in MACS.


Variant ID.  4930
Epitope Seq.  KRWIILGLNK
Variant Seq.  rRWIqLGLqK
Mutations K/R I/Q N/Q
Epitope Location K1R I5Q N9Q
HXB2 Location K263R I267Q N271Q
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Other, Relative replication capacity assay
Note After mutagenesis and passaging through human T cells, 60 single nucleotide mutations were observed in epitope KRWIILGLNK (known to bind to B2705) & variant rRWIqLGLqK (known to bind to B2703) with a log transformation of mean fitness score, relative to NL4-3, of -0.5469.

References

Du2017 Yushen Du, Tian-Hao Zhang, Lei Dai, Xiaojuan Zheng, Aleksandr M. Gorin, John Oishi, Ting-Ting Wu, Janice M. Yoshizawa, Xinmin Li, Otto O. Yang, Otoniel Martinez-Maza, Roger Detels, and Ren Sun. Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes. mBio, 8(6), 28 Nov 2017. PubMed ID: 29184023. Show all entries for this paper.


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