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Found 1 matching record:

Displaying record number 62520

HXB2 Location  Vif(61-69)   Vif Epitope Map
View variants at this location
Epitope DAKLVITTY   Epitope Alignment
Variants
DAKLVvTTY   non-susceptible form
eAKLVITTY   non-susceptible form
Epitope Name Vif-DY9
Species (MHC/HLA human(C*12:02)

Variant Details

Showing all: 2 variant(s).


Variant ID.  4479
Epitope Seq.  DAKLVITTY
Variant Seq.  DAKLVvTTY
Mutations I/V
Epitope Location I6V
HXB2 Location I66V
Mutation Type NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, T2 stabilization assay
Note I66V was observed in more than 5/20 chronically HIV-1-infected Japanese C*12:02+ subjects, but despite measurable affinity for C*12:02, a DAKLVvTTY-specific CTL response was not detected in the same cohort.


Variant ID.  4489
Epitope Seq.  DAKLVITTY
Variant Seq.  eAKLVITTY
Mutations D/E
Epitope Location D1E
HXB2 Location D61E
Mutation Type NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, T2 stabilization assay
Note D61E was observed in more than 5/20 chronically HIV-1-infected Japanese C*12:02+ subjects, but despite measurable affinity for C*12:02, a eAKLVITTY-specific CTL response was not detected in the same cohort.

References

Chikata2019 Takayuki Chikata, Wayne Paes, Tomohiro Akahoshi, Thomas Partridge, Hayato Murakoshi, Hiroyuki Gatanaga, Nicola Ternette, Shinichi Oka, Persephone Borrow, and Masafumi Takiguchi. Identification of Immunodominant HIV-1 Epitopes Presented by HLA-C*12:02, a Protective Allele, Using an Immunopeptidomics Approach. J. Virol., 93(17), 1 Sep 2019. PubMed ID: 31217245. Show all entries for this paper.


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