HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 1 matching record:

Displaying record number 62517

HXB2 Location  Tat(39-47)   Tat Epitope Map
View variants at this location
Epitope MTKALGISY   Epitope Alignment
Variants
TKKGLGISY   non-susceptible form
IKKGLGISY   non-susceptible form
Epitope Name Tat-MY9
Species (MHC/HLA human(C*12:02)

Variant Details

Showing all: 2 variant(s).


Variant ID.  4475
Epitope Seq.  MTKALGISY
Variant Seq.  TKKGLGISY
Mutations M/T T/K A/G
Epitope Location M1T T2K A4G
HXB2 Location M39T T40K A42G
Mutation Type NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, T2 stabilization assay
Note M39T, T40K, and A42G were observed in more than 5/20 chronically HIV-1-infected Japanese C*12:02+ subjects, but neither a measurable affinity for C*12:02 or a TKKGLGISY-specific CTL response was detected.


Variant ID.  4476
Epitope Seq.  MTKALGISY
Variant Seq.  IKKGLGISY
Mutations M/I T/K A/G
Epitope Location M1I T2K A4G
HXB2 Location M39I T40K A42G
Mutation Type NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, T2 stabilization assay
Note M39I, T40K, and A42G were observed in more than 5/20 chronically HIV-1-infected Japanese C*12:02+ subjects, but despite measurable affinity for C*12:02, a IKKGLGISY-specific CTL response was not detected in the same cohort.

References

Chikata2019 Takayuki Chikata, Wayne Paes, Tomohiro Akahoshi, Thomas Partridge, Hayato Murakoshi, Hiroyuki Gatanaga, Nicola Ternette, Shinichi Oka, Persephone Borrow, and Masafumi Takiguchi. Identification of Immunodominant HIV-1 Epitopes Presented by HLA-C*12:02, a Protective Allele, Using an Immunopeptidomics Approach. J. Virol., 93(17), 1 Sep 2019. PubMed ID: 31217245. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health