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Found 1 matching record:

Displaying record number 62489

HXB2 Location  Gag(321-329)   Gag Epitope Map
View variants at this location
Epitope LLIQNANPD   Epitope Alignment
Variants
LLIQnANPD   observed variant; replicative capacity is not abrogated; susceptible form
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  4456
Epitope Seq.  LLIQNANPD
Variant Seq.  LLIQnANPD
Mutations N/n
Epitope Location N5n
HXB2 Location N325n
Mutation Type OV: observed variant
RCOK: replicative capacity is not abrogated
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Longitudinal study, Other, Relative replication capacity assay
Note Synonymous mutation N323tc appeared at 175d post-screening, and was fixed to completion (100%) by 670d post-screening, indicating strong selection. No T-cell- or Ab-responses were detected against the mutant, and it was not a cryptic epitope, showing host-specific, non-adaptive immune selection pressures. The mutant was not significantly less fit than T/F over 3 comparative passages.

References

Liu2017a Donglai Liu, Chu Wang, Bhavna Hora, Tao Zuo, Nilu Goonetilleke, Michael K. P. Liu, Mark Berrong, Guido Ferrari, Andrew J. McMichael, Tanmoy Bhattacharya, Alan S. Perelson, and Feng Gao. A Strongly Selected Mutation in the HIV-1 Genome Is Independent of T Cell Responses and Neutralizing Antibodies. Retrovirology, 14(1):46, 10 Oct 2017. PubMed ID: 29017536. Show all entries for this paper.


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