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Displaying record number 62489

HXB2 Location Gag(321-329) Gag Epitope Map
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Epitope

LLIQNANPD

Epitope Alignment

Variants

LLIQnANPD observed variant; replicative capacity is not abrogated; susceptible form

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`4456`
Epitope Seq.	`LLIQNANPD`
Variant Seq.	`LLIQnANPD`
Mutations	N/n
Epitope Location	N5n
HXB2 Location	N325n
Mutation Type	OV: observed variant RCOK: replicative capacity is not abrogated SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, Longitudinal study, Other, Relative replication capacity assay
Note	Synonymous mutation N323tc appeared at 175d post-screening, and was fixed to completion (100%) by 670d post-screening, indicating strong selection. No T-cell- or Ab-responses were detected against the mutant, and it was not a cryptic epitope, showing host-specific, non-adaptive immune selection pressures. The mutant was not significantly less fit than T/F over 3 comparative passages.

References

Liu2017a Donglai Liu, Chu Wang, Bhavna Hora, Tao Zuo, Nilu Goonetilleke, Michael K. P. Liu, Mark Berrong, Guido Ferrari, Andrew J. McMichael, Tanmoy Bhattacharya, Alan S. Perelson, and Feng Gao. A Strongly Selected Mutation in the HIV-1 Genome Is Independent of T Cell Responses and Neutralizing Antibodies. Retrovirology, 14(1):46, 10 Oct 2017. PubMed ID: 29017536. Show all entries for this paper.