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Displaying record number 62315

HXB2 Location  gp160(217-226)   gp160 Epitope Map
View variants at this location
Epitope YCAPAGFAIL   Epitope Alignment
Variants
YCAPAGFAIi   escape documented in this paper; replicative capacity is not abrogated
YCAPAGlAIi   escape documented in this paper
YCtPAGFAIi   escape documented in this paper
YCAPAGFAni   escape documented in this paper
YCAPAGFtIi   escape documented in this paper
Epitope Name YL10
Species (MHC/HLA human(C*01)

Variant Details

Showing all: 5 variant(s).


Variant ID.  4429
Epitope Seq.  YCAPAGFAIL
Variant Seq.  YCAPAGFAIi
Mutations L/I
Epitope Location L10I
HXB2 Location L97I
Mutation Type E: escape documented in this paper
RCOK: replicative capacity is not abrogated
Epitope Subtype B
Variant Subtype B
Method CD4 T-cell Elispot - IFNy, Longitudinal study, Other, Sequence
Note Fitness neutral escape mutant YCAPAGFAIi was seen from 155-1035 DPS (days post symptoms) in subject PIC1362. It is also known as the L226I mutant.


Variant ID.  4430
Epitope Seq.  YCAPAGFAIL
Variant Seq.  YCAPAGlAIi
Mutations L/I F/L
Epitope Location L10I F7L
HXB2 Location L97I F94L
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method CD4 T-cell Elispot - IFNy, Longitudinal study, Other, Sequence
Note Escape mutant YCAPAGlAIi was seen at 580 DPS (days post symptoms) in subject PIC1362.


Variant ID.  4431
Epitope Seq.  YCAPAGFAIL
Variant Seq.  YCtPAGFAIi
Mutations L/I A/T
Epitope Location L10I A3T
HXB2 Location L97I A90T
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method CD4 T-cell Elispot - IFNy, Longitudinal study, Other, Sequence
Note Escape mutant YCtPAGFAIi was seen 769-826 DPS (days post symptoms) in subject PIC1362.


Variant ID.  4432
Epitope Seq.  YCAPAGFAIL
Variant Seq.  YCAPAGFAni
Mutations L/I I/N
Epitope Location L10I I9N
HXB2 Location L97I I96N
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method CD4 T-cell Elispot - IFNy, Longitudinal study, Other, Sequence
Note Escape mutant YCAPAGFAni was seen only at 1035 DPS (days post symptoms) in subject PIC1362.


Variant ID.  4433
Epitope Seq.  YCAPAGFAIL
Variant Seq.  YCAPAGFtIi
Mutations L/I A/T
Epitope Location L10I A8T
HXB2 Location L97I A95T
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method CD4 T-cell Elispot - IFNy, Longitudinal study, Other, Sequence
Note Escape mutant YCAPAGFtIi was seen at 344 DPS (days post symptoms) in subject PIC1362.

References

Troyer2009 Ryan M. Troyer, John McNevin, Yi Liu, Shao Chong Zhang, Randall W. Krizan, Awet Abraha, Denis M. Tebit, Hong Zhao, Santiago Avila, Michael A. Lobritz, M. Juliana McElrath, Sylvie Le Gall, James I. Mullins, and Eric J. Arts. Variable Fitness Impact of HIV-1 Escape Mutations to Cytotoxic T Lymphocyte (CTL) Response. PLoS Pathog., 5(4):e1000365, Apr 2009. PubMed ID: 19343217. Show all entries for this paper.


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