HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | gp160(217-226) | gp160 Epitope Map
View variants at this location |
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| Epitope |
YCAPAGFAIL
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Epitope Alignment | ||||||||||||||||
| Variants |
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| Epitope Name | YL10 | |||||||||||||||||
| Species (MHC/HLA) | human(C*01) | |||||||||||||||||
Showing all: 5 variant(s).
| Variant ID. | 4429 |
|---|---|
| Epitope Seq. | YCAPAGFAIL |
| Variant Seq. | YCAPAGFAIi |
| Mutations | L/I |
| Epitope Location | L10I |
| HXB2 Location | L97I |
| Mutation Type | E: escape documented in this paper RCOK: replicative capacity is not abrogated |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD4 T-cell Elispot - IFNy, Longitudinal study, Other, Sequence |
| Note | Fitness neutral escape mutant YCAPAGFAIi was seen from 155-1035 DPS (days post symptoms) in subject PIC1362. It is also known as the L226I mutant. |
| Variant ID. | 4430 |
|---|---|
| Epitope Seq. | YCAPAGFAIL |
| Variant Seq. | YCAPAGlAIi |
| Mutations | L/I F/L |
| Epitope Location | L10I F7L |
| HXB2 Location | L97I F94L |
| Mutation Type | E: escape documented in this paper |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD4 T-cell Elispot - IFNy, Longitudinal study, Other, Sequence |
| Note | Escape mutant YCAPAGlAIi was seen at 580 DPS (days post symptoms) in subject PIC1362. |
| Variant ID. | 4431 |
|---|---|
| Epitope Seq. | YCAPAGFAIL |
| Variant Seq. | YCtPAGFAIi |
| Mutations | L/I A/T |
| Epitope Location | L10I A3T |
| HXB2 Location | L97I A90T |
| Mutation Type | E: escape documented in this paper |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD4 T-cell Elispot - IFNy, Longitudinal study, Other, Sequence |
| Note | Escape mutant YCtPAGFAIi was seen 769-826 DPS (days post symptoms) in subject PIC1362. |
| Variant ID. | 4432 |
|---|---|
| Epitope Seq. | YCAPAGFAIL |
| Variant Seq. | YCAPAGFAni |
| Mutations | L/I I/N |
| Epitope Location | L10I I9N |
| HXB2 Location | L97I I96N |
| Mutation Type | E: escape documented in this paper |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD4 T-cell Elispot - IFNy, Longitudinal study, Other, Sequence |
| Note | Escape mutant YCAPAGFAni was seen only at 1035 DPS (days post symptoms) in subject PIC1362. |
| Variant ID. | 4433 |
|---|---|
| Epitope Seq. | YCAPAGFAIL |
| Variant Seq. | YCAPAGFtIi |
| Mutations | L/I A/T |
| Epitope Location | L10I A8T |
| HXB2 Location | L97I A95T |
| Mutation Type | E: escape documented in this paper |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD4 T-cell Elispot - IFNy, Longitudinal study, Other, Sequence |
| Note | Escape mutant YCAPAGFtIi was seen at 344 DPS (days post symptoms) in subject PIC1362. |
Troyer2009 Ryan M. Troyer, John McNevin, Yi Liu, Shao Chong Zhang, Randall W. Krizan, Awet Abraha, Denis M. Tebit, Hong Zhao, Santiago Avila, Michael A. Lobritz, M. Juliana McElrath, Sylvie Le Gall, James I. Mullins, and Eric J. Arts. Variable Fitness Impact of HIV-1 Escape Mutations to Cytotoxic T Lymphocyte (CTL) Response. PLoS Pathog., 5(4):e1000365, Apr 2009. PubMed ID: 19343217. Show all entries for this paper.