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Displaying record number 62305

HXB2 Location gp160(61-69) gp160 Epitope Map
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YETEVHNVW

`YkTEVHNVW`		observed variant
`YEkEVHNVW`		observed variant
`YgTEVHNVW`		observed variant
`YqTEVHNVW`		observed variant
`YEaEVHNVW`		observed variant
`YEaEVHsVW`		observed variant
`YETgiHNVW`		observed variant
`YETEaHNVW`		observed variant; replicative capacity is not abrogated; susceptible form
`YdTEaHNVW`		escape documented in this paper; replicative capacity/ fitness enhanced; observed variant
`hETEaHNVW`		observed variant
`YdTEVHNVW`		escape documented in this paper; replicative capacity/ fitness enhanced; observed variant
`YdiEVHNVW`		escape documented in this paper; observed variant

Epitope Name YW9

Species (MHC/HLA) human(B*18)

Variant Details

Showing all: 12 variant(s).

Variant ID.	`4408`
Epitope Seq.	`YETEVHNVW`
Variant Seq.	`YkTEVHNVW`
Mutations	E/K
Epitope Location	E2K
HXB2 Location	E62K
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	Longitudinal study, Other, Sequence
Note	Mutant YkTEVHNVW was seen in patient PIC1362 from 50-190 DPS (days post symptoms).

Variant ID.	`4409`
Epitope Seq.	`YETEVHNVW`
Variant Seq.	`YEkEVHNVW`
Mutations	T/K
Epitope Location	T3K
HXB2 Location	T63K
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	Longitudinal study, Other, Sequence
Note	Mutant, YEkEVHNVW, was seen in patient PIC1362 from 155-190 DPS (days post symptoms).

Variant ID.	`4410`
Epitope Seq.	`YETEVHNVW`
Variant Seq.	`YgTEVHNVW`
Mutations	E/G
Epitope Location	E2G
HXB2 Location	E62G
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	Longitudinal study, Other, Sequence
Note	Mutant, YgTEVHNVW, was seen in patient PIC1362 at 155 DPS (days post symptoms).

Variant ID.	`4411`
Epitope Seq.	`YETEVHNVW`
Variant Seq.	`YqTEVHNVW`
Mutations	E/Q
Epitope Location	E2Q
HXB2 Location	E62Q
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	Longitudinal study, Other, Sequence
Note	Mutant YqTEVHNVW was seen in patient PIC1362 only at 155 DPS (days post symptoms).

Variant ID.	`4412`
Epitope Seq.	`YETEVHNVW`
Variant Seq.	`YEaEVHNVW`
Mutations	T/A
Epitope Location	T3A
HXB2 Location	T63A
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	Longitudinal study, Other, Sequence
Note	Mutant YYEaEVHNVW was seen in patient PIC1362 only at 155 DPS (days post symptoms).

Variant ID.	`4413`
Epitope Seq.	`YETEVHNVW`
Variant Seq.	`YEaEVHsVW`
Mutations	T/A N/S
Epitope Location	T3A N7S
HXB2 Location	T63A N67S
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	Longitudinal study, Other, Sequence
Note	Mutant YYEaEVHsVW was seen in patient PIC1362 only at 155 DPS (days post symptoms).

Variant ID.	`4414`
Epitope Seq.	`YETEVHNVW`
Variant Seq.	`YETgiHNVW`
Mutations	E/G V/I
Epitope Location	E4G V5I
HXB2 Location	E64G V65I
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	Longitudinal study, Other, Sequence
Note	Mutant YETgiHNVW was seen in patient PIC1362 only at 190 DPS (days post symptoms).

Variant ID.	`4415`
Epitope Seq.	`YETEVHNVW`
Variant Seq.	`YETEaHNVW`
Mutations	V/A
Epitope Location	V5A
HXB2 Location	V65A
Mutation Type	OV: observed variant RCOK: replicative capacity is not abrogated SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study, Other, Relative replication capacity assay, Sequence
Note	Mutant YETEaHNVW was seen in patient PIC1362 from 50-190 DPS (days post symptoms). This fitness neutral V65A mutant showed enhanced CTL recognition.

Variant ID.	`4416`
Epitope Seq.	`YETEVHNVW`
Variant Seq.	`YdTEaHNVW`
Mutations	E/D V/A
Epitope Location	E2D V5A
HXB2 Location	E62D V65A
Mutation Type	E: escape documented in this paper F: replicative capacity/ fitness enhanced OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	Longitudinal study, Other, Relative replication capacity assay, Sequence
Note	Mutant YdTEaHNVW was seen in patient PIC1362 from 344-826 DPS (days post symptoms), it had become the sole form of the epitope by 769 DPI. This linked dual mutant, E62D/V65A, encoded a fitter virus that was resistant to CTL recognition and MHC display; resisting CTL pressure.

Variant ID.	`4417`
Epitope Seq.	`YETEVHNVW`
Variant Seq.	`hETEaHNVW`
Mutations	Y/H V/A
Epitope Location	Y1H V5A
HXB2 Location	Y61H V65A
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	Longitudinal study, Other, Sequence
Note	Mutant YdTEaHNVW was seen in patient PIC1362 at 344 DPS (days post symptoms).

Variant ID.	`4418`
Epitope Seq.	`YETEVHNVW`
Variant Seq.	`YdTEVHNVW`
Mutations	E/D
Epitope Location	E2D
HXB2 Location	E62D
Mutation Type	E: escape documented in this paper F: replicative capacity/ fitness enhanced OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study, Other, Relative replication capacity assay, Sequence
Note	Mutant YdTEVHNVW was seen in patient PIC1362 from 155-769 DPS (days post symptoms). This E62D mutant had increased fitness but displayed peptides modestly and was resistant to CTL recognition.

Variant ID.	`4419`
Epitope Seq.	`YETEVHNVW`
Variant Seq.	`YdiEVHNVW`
Mutations	E/D T/I
Epitope Location	E2D T3I
HXB2 Location	E62D T63I
Mutation Type	E: escape documented in this paper OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	Longitudinal study, Other, Sequence
Note	Mutant YdiEVHNVW was seen in patient PIC1362 at only 344 DPS (days post symptoms).

References

Troyer2009 Ryan M. Troyer, John McNevin, Yi Liu, Shao Chong Zhang, Randall W. Krizan, Awet Abraha, Denis M. Tebit, Hong Zhao, Santiago Avila, Michael A. Lobritz, M. Juliana McElrath, Sylvie Le Gall, James I. Mullins, and Eric J. Arts. Variable Fitness Impact of HIV-1 Escape Mutations to Cytotoxic T Lymphocyte (CTL) Response. PLoS Pathog., 5(4):e1000365, Apr 2009. PubMed ID: 19343217. Show all entries for this paper.