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Displaying record number 62232

HXB2 Location  Vif(48-57)   Vif Epitope Map
View variants at this location
Epitope HPKVSSEVHI   Epitope Alignment
Variants
HPKVSSEVHv   observed variant
HPKVSSEiHI   observed variant
HPKVSSEVHt   observed variant
nPKVSSEVHI   observed variant
HPKiSSEVHI   observed variant
HPrVSSEVHI   observed variant
Epitope Name Vif-HI10
Species (MHC/HLA human(B*42)

Variant Details

Showing all: 6 variant(s).


Variant ID.  4298
Epitope Seq.  HPKVSSEVHI
Variant Seq.  HPKVSSEVHv
Mutations I/V
Epitope Location I10V
HXB2 Location I57V
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Sequence
Note HPKVSSEVHv (I57V) was observed in B*42+ (which is a restricting HLA for HI10) subject 517-M when her B*42+ child, 517-C, was 0.25 years old. However, it was not observed in 517-C. It was observed as a covariant with V55I.


Variant ID.  4299
Epitope Seq.  HPKVSSEVHI
Variant Seq.  HPKVSSEiHI
Mutations V/I
Epitope Location V8I
HXB2 Location V55I
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Sequence
Note HPKVSSEiHI (V55I) was observed in B*42+ (which is a restricting HLA for HI10) subject 517-M when her B*42+ child, 517-C, was 0.25 years old. However, it was not observed in 517-C. It was sometimes seen as a covariant with I57V.


Variant ID.  4300
Epitope Seq.  HPKVSSEVHI
Variant Seq.  HPKVSSEVHt
Mutations I/T
Epitope Location I10T
HXB2 Location I57T
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Sequence
Note HPKVSSEVHt (I57T) was observed in B*42+ (which is a restricting HLA for HI10) subject 517-M when her B*42+ child, 517-C, was 6 years old.


Variant ID.  4301
Epitope Seq.  HPKVSSEVHI
Variant Seq.  nPKVSSEVHI
Mutations H/N
Epitope Location H1N
HXB2 Location H48N
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Sequence
Note nPKVSSEVHI (H48N) arose in B*42+ (which is a restricting HLA for HI10) subject 517-C between 0.2 and 2.5 years. It was sometimes observed as a covariant with V51I.


Variant ID.  4302
Epitope Seq.  HPKVSSEVHI
Variant Seq.  HPKiSSEVHI
Mutations V/I
Epitope Location V4I
HXB2 Location V51I
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Sequence
Note HPKiSSEVHI (V51I) arose in B*42+ (which is a restricting HLA for HI10) subject 517-C between 0.2 and 2.5 years. It was sometimes observed as a covariant with H48N or K50R.


Variant ID.  4303
Epitope Seq.  HPKVSSEVHI
Variant Seq.  HPrVSSEVHI
Mutations K/R
Epitope Location K3R
HXB2 Location K50R
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Sequence
Note HPrVSSEVHI (K50R) arose in B*42+ (which is a restricting HLA for HI10) subject 517-C between 2.5 and 5 years. It was sometimes observed as a covariant with V51I.

References

Leitman2017 Ellen M. Leitman, Christina F. Thobakgale, Emily Adland, M. Azim Ansari, Jayna Raghwani, Andrew J. Prendergast, Gareth Tudor-Williams, Photini Kiepiela, Joris Hemelaar, Jacqui Brener, Ming-Han Tsai, Masahiko Mori, Lynn Riddell, Graz Luzzi, Pieter Jooste, Thumbi Ndung'u, Bruce D. Walker, Oliver G. Pybus, Paul Kellam, Vivek Naranbhai, Philippa C. Matthews, Astrid Gall, and Philip J. R. Goulder. Role of HIV-Specific CD8+ T Cells in Pediatric HIV Cure Strategies after Widespread Early Viral Escape. J. Exp. Med., 214(11):3239-3261, 6 Nov 2017. PubMed ID: 28983013. Show all entries for this paper.


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