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Found 1 matching record:

Displaying record number 62231

HXB2 Location  Pol(743-751)   Pol Epitope Map
View variants at this location
Epitope LPPIVAKEI   Epitope Alignment
Variants
LPPvVAKEI   literature escape
LPPIVArEI   literature escape
Epitope Name Pol-LI9
Species (MHC/HLA human(B*42)

Variant Details

Showing all: 2 variant(s).


Variant ID.  4296
Epitope Seq.  LPPIVAKEI
Variant Seq.  LPPvVAKEI
Mutations I/V
Epitope Location I4V
HXB2 Location I746V
Mutation Type LE: literature escape
Epitope Subtype C
Variant Subtype C
Method Sequence
Note LPPvVAKEI (I746V) is a documented escape variant. It was observed at all sampling time points in B*42+ (which is a restricting HLA for LI9) subject 517-M and her B*42+ child, 517-C. It was sometimes observed as a covariant with K749R.


Variant ID.  4297
Epitope Seq.  LPPIVAKEI
Variant Seq.  LPPIVArEI
Mutations K/R
Epitope Location K7R
HXB2 Location K749R
Mutation Type LE: literature escape
Epitope Subtype C
Variant Subtype C
Method Sequence
Note LPPIVArEI (K749) is a documented escape variant. It was observed at all sampling time points in B*42+ (which is a restricting HLA for LI9) subject 517-M and her B*42+ child, 517-C. It was sometimes observed as a covariant with I746V.

References

Leitman2017 Ellen M. Leitman, Christina F. Thobakgale, Emily Adland, M. Azim Ansari, Jayna Raghwani, Andrew J. Prendergast, Gareth Tudor-Williams, Photini Kiepiela, Joris Hemelaar, Jacqui Brener, Ming-Han Tsai, Masahiko Mori, Lynn Riddell, Graz Luzzi, Pieter Jooste, Thumbi Ndung'u, Bruce D. Walker, Oliver G. Pybus, Paul Kellam, Vivek Naranbhai, Philippa C. Matthews, Astrid Gall, and Philip J. R. Goulder. Role of HIV-Specific CD8+ T Cells in Pediatric HIV Cure Strategies after Widespread Early Viral Escape. J. Exp. Med., 214(11):3239-3261, 6 Nov 2017. PubMed ID: 28983013. Show all entries for this paper.


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