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HIV Molecular Immunology Database

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Found 1 matching record:

Displaying record number 62134

HXB2 Location  Nef(134-143)   Nef Epitope Map
View variants at this location
Epitope RYPLTFGWCF   Epitope Alignment
Variants
RfPLTFGWCF   altered HLA expression; observed variant
Species (MHC/HLA human(A*23:01, A*24)

Variant Details

Showing all: 1 variant(s).


Variant ID.  4206
Epitope Seq.  RYPLTFGWCF
Variant Seq.  RfPLTFGWCF
Mutations Y/F
Epitope Location Y2F
HXB2 Location Y135F
Mutation Type AHE: altered HLA expression
OV: observed variant
Method Other, Relative replication capacity assay
Note For mutation 135F, replication capacities, CD4 down-modulation capacities, and HLA-I down-modulation capacities expressed relative to that of the wild-type LANL consensus B Nef are 1.143, 1.003 and 0.974 respectively. Thus 135F has no significant deleterious effect on this epitope.

References

Barton2019 John P. Barton, Erasha Rajkoomar, Jaclyn K. Mann, Dariusz K. Murakowski, Mako Toyoda, Macdonald Mahiti, Phillip Mwimanzi, Takamasa Ueno, Arup K. Chakraborty, and Thumbi Ndung'u. Modelling and In Vitro Testing of the HIV-1 Nef Fitness Landscape. Virus Evol., 5(2):vez029, Jul 2019. PubMed ID: 31392033. Show all entries for this paper.


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