Found 1 matching record:
HXB2 Location | Nef(134-143) | Nef Epitope Map
View variants at this location |
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Epitope |
RYPLTFGWCF
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Epitope Alignment | ||||
Variants |
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Species (MHC/HLA) | human(A*23:01, A*24) |
Showing all: 1 variant(s).
Variant ID. | 4206 |
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Epitope Seq. | RYPLTFGWCF |
Variant Seq. | RfPLTFGWCF |
Mutations | Y/F |
Epitope Location | Y2F |
HXB2 Location | Y135F |
Mutation Type | AHE: altered HLA expression OV: observed variant |
Method | Other, Relative replication capacity assay |
Note | For mutation 135F, replication capacities, CD4 down-modulation capacities, and HLA-I down-modulation capacities expressed relative to that of the wild-type LANL consensus B Nef are 1.143, 1.003 and 0.974 respectively. Thus 135F has no significant deleterious effect on this epitope. |
Barton2019 John P. Barton, Erasha Rajkoomar, Jaclyn K. Mann, Dariusz K. Murakowski, Mako Toyoda, Macdonald Mahiti, Phillip Mwimanzi, Takamasa Ueno, Arup K. Chakraborty, and Thumbi Ndung'u. Modelling and In Vitro Testing of the HIV-1 Nef Fitness Landscape. Virus Evol., 5(2):vez029, Jul 2019. PubMed ID: 31392033. Show all entries for this paper.
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