HIV molecular immunology database
Found 1 matching record:
|HXB2 Location||Nef(71-79)|| Nef Epitope Map
View variants at this location
|Species (MHC/HLA)||human(B*0702, B*8101)|
Showing all: 1 variant(s).
|Mutation Type||AHE: altered HLA expression
OV: observed variant
RCR: replicative capacity reduced
|Method||Other, Relative replication capacity assay|
|Note||For mutation 76V, replication capacities, CD4 down-modulation capacities, and HLA-I down-modulation capacities expressed relative to that of the wild-type LANL consensus B Nef are 0.843, 1.006 and 0.931 respectively. Thus L76V has a very moderate effect on this epitope and only significantly on replication.|
Barton2019 John P. Barton, Erasha Rajkoomar, Jaclyn K. Mann, Dariusz K. Murakowski, Mako Toyoda, Macdonald Mahiti, Phillip Mwimanzi, Takamasa Ueno, Arup K. Chakraborty, and Thumbi Ndung'u. Modelling and in vitro testing of the HIV-1 Nef fitness landscape. Virus Evol, 5(2):vez029 doi, Jul 2019. PubMed ID: 31392033 Show all entries for this paper.