HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 62132

HXB2 Location  Nef(71-79)   Nef Epitope Map
View variants at this location
Epitope RPQVPLRPM   Epitope Alignment
RPQVPvRPM   altered HLA expression; observed variant; replicative capacity reduced
Species (MHC/HLA human(B*0702, B*8101)

Variant Details

Showing all: 1 variant(s).

Variant ID.  4204
Epitope Seq.  RPQVPLRPM
Variant Seq.  RPQVPvRPM
Mutations L/V
Epitope Location L6V
HXB2 Location L76V
Mutation Type AHE: altered HLA expression
OV: observed variant
RCR: replicative capacity reduced
Method Other, Relative replication capacity assay
Note For mutation 76V, replication capacities, CD4 down-modulation capacities, and HLA-I down-modulation capacities expressed relative to that of the wild-type LANL consensus B Nef are 0.843, 1.006 and 0.931 respectively. Thus L76V has a very moderate effect on this epitope and only significantly on replication.


Barton2019 John P. Barton, Erasha Rajkoomar, Jaclyn K. Mann, Dariusz K. Murakowski, Mako Toyoda, Macdonald Mahiti, Phillip Mwimanzi, Takamasa Ueno, Arup K. Chakraborty, and Thumbi Ndung'u. Modelling and in vitro testing of the HIV-1 Nef fitness landscape. Virus Evol, 5(2):vez029 doi, Jul 2019. PubMed ID: 31392033 Show all entries for this paper.

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