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Found 1 matching record:

Displaying record number 62131

HXB2 Location  Nef(71-81)   Nef Epitope Map
View variants at this location
Epitope RPQVPLRPMTY   Epitope Alignment
Variants
kPQVPLRPMTY   altered HLA expression; observed variant; replicative capacity reduced
Species (MHC/HLA human(B35)

Variant Details

Showing all: 1 variant(s).


Variant ID.  4202
Epitope Seq.  RPQVPLRPMTY
Variant Seq.  kPQVPLRPMTY
Mutations R/K
Epitope Location R1K
HXB2 Location R71K
Mutation Type AHE: altered HLA expression
OV: observed variant
RCR: replicative capacity reduced
Method Other, Relative replication capacity assay
Note For mutation 71K, replication capacities, CD4 down-modulation capacities, and HLA-I down-modulation capacities expressed relative to that of the wild-type LANL consensus B Nef are 0.854, 1.002 and 0.972 respectively. Thus R71K has a very moderate effect on this epitope and only significantly on replication.

References

Barton2019 John P. Barton, Erasha Rajkoomar, Jaclyn K. Mann, Dariusz K. Murakowski, Mako Toyoda, Macdonald Mahiti, Phillip Mwimanzi, Takamasa Ueno, Arup K. Chakraborty, and Thumbi Ndung'u. Modelling and in vitro testing of the HIV-1 Nef fitness landscape. Virus Evol, 5(2):vez029 doi, Jul 2019. PubMed ID: 31392033 Show all entries for this paper.


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