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Displaying record number 62016

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KtWIILGLNK   diminished response
KkWIImGLNK   diminished response
KRWIImGLNK   susceptible form
KqWIILGLNK   susceptible form
Epitope Name KK10
Species (MHC/HLA human

Variant Details

Showing all: 4 variant(s).


Variant ID.  4172
Epitope Seq.  KRWIILGLNK
Variant Seq.  KtWIILGLNK
Mutations R/T
Epitope Location R2T
HXB2 Location R264T
Mutation Type DR: diminished response
Method CTL suppression of replication, HLA binding, Intracellular cytokine staining, Other
Note R2T escape mutant, KtWIILGLNK, elicited diminished immune cytotoxicity as compared to WT KK10-transduced effector T cells.


Variant ID.  4173
Epitope Seq.  KRWIILGLNK
Variant Seq.  KkWIImGLNK
Mutations R/K L/M
Epitope Location R2K L6M
HXB2 Location R264K L268M
Mutation Type DR: diminished response
Method CTL suppression of replication, HLA binding, Intracellular cytokine staining, Other
Note R2KL6M escape mutant, KkWIImGLNK, elicited diminished immune cytotoxicity as compared to WT KK10-transduced effector T cells.


Variant ID.  4175
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIImGLNK
Mutations L/M
Epitope Location L6M
HXB2 Location L268M
Mutation Type SF: susceptible form
Method CTL suppression of replication, HLA binding, Intracellular cytokine staining, Other
Note L6M escape mutant, KRWIImGLNK, elicited similar immune cytotoxicity as WT KK10-transduced effector T cells.


Variant ID.  4176
Epitope Seq.  KRWIILGLNK
Variant Seq.  KqWIILGLNK
Mutations R/Q
Epitope Location R2Q
HXB2 Location R264Q
Mutation Type SF: susceptible form
Method CTL suppression of replication, HLA binding, Intracellular cytokine staining, Other
Note R2Q escape mutant, KqWIILGLNK, elicited similar immune cytotoxicity as WT KK10-transduced effector T cells.

References

Joglekar2018 Alok V. Joglekar, Zhe Liu, Jeffrey K. Weber, Yong Ouyang, John D. Jeppson, Won Jun Noh, Pedro A. Lamothe-Molina, Huabiao Chen, Seung-Gu Kang, Michael T. Bethune, Ruhong Zhou, Bruce D. Walker, and David Baltimore. T Cell Receptors for the HIV KK10 Epitope from Patients with Differential Immunologic Control Are Functionally Indistinguishable. Proc. Natl. Acad. Sci. U.S.A., 115(8):1877-1882, 20 Feb 2018. PubMed ID: 29437954. Show all entries for this paper.


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