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Displaying record number 61982

HXB2 Location  Gag(369-377)   Gag Epitope Map
View variants at this location
Epitope QVQHTNIMM   Epitope Alignment
Variants
QaQqpNVMM   susceptible form
QanantaIM   susceptible form
QVngntaiM   susceptible form
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 3 variant(s).


Variant ID.  4156
Epitope Seq.  QVQHTNIMM
Variant Seq.  QaQqpNVMM
Mutations V/A H/Q T/P I/V
Epitope Location V2A H4Q T5P I7V
HXB2 Location V370A H372Q T373P I375V
Mutation Type SF: susceptible form
Epitope Subtype A, D
Variant Subtype A, D
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 5/8 female B*7202+ patients responded to this novel variant of QVQHTNIMM, QaQqpNVMM, with a mean of 96 SFU/million cells.


Variant ID.  4157
Epitope Seq.  QVQHTNIMM
Variant Seq.  QanantaIM
Mutations V/A Q/N H/A T/N N/T I/A M/I
Epitope Location V2A Q3N H4A T5N N6T I7A M8I
HXB2 Location V370A Q371N H372A T373N N374T I375A M376I
Mutation Type SF: susceptible form
Epitope Subtype A, D
Variant Subtype A, D
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 6/8 female B*7202+ patients responded to this novel variant of QVQHTNIMM, QanantaIM, with a mean of 109 SFU/million cells.


Variant ID.  4158
Epitope Seq.  QVQHTNIMM
Variant Seq.  QVngntaiM
Mutations Q/N H/G T/N N/T I/A M/I
Epitope Location Q3N H4G T5N N6T I7A M8I
HXB2 Location Q371N H372G T373N N374T I375A M376I
Mutation Type SF: susceptible form
Epitope Subtype A, D
Variant Subtype A, D
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 6/8 female B*7202+ patients responded to this novel variant of QVQHTNIMM, QVngntaiM, with a mean of 99 SFU/million cells.

References

Luo2012 Ma Luo, Christina A. Daniuk, Tamsir O. Diallo, Rupert E. Capina, Joshua Kimani, Charles Wachihi, Makubo Kimani, Thomas Bielawny, Trevor Peterson, Mark G. R. Mendoza, Sandra Kiazyk, T. Blake Ball, and Francis A. Plummer. For Protection from HIV-1 Infection, More Might Not Be Better: A Systematic Analysis of HIV Gag Epitopes of Two Alleles Associated with Different Outcomes of HIV-1 Infection. J. Virol., 86(2):1166-1180, Jan 2012. PubMed ID: 22072744. Show all entries for this paper.


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