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Displaying record number 61910

HXB2 Location Pol(464-473) Pol Epitope Map
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Epitope

ILKEPVHGVY

Epitope Alignment

Variants

ILKEPVHGaY altered KIR binding or increased/decreased off-rate

Epitope Name Pol IY10

Species (MHC/HLA) human(C*12:02)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`4128`
Epitope Seq.	`ILKEPVHGVY`
Variant Seq.	`ILKEPVHGaY`
Mutations	V/A
Epitope Location	V9A
HXB2 Location	V472A
Mutation Type	AKB: altered KIR binding or increased/decreased off-rate
Method	CTL suppression of replication, HLA binding, Other
Note	The 9A mutant, ILKEPVHGaY, gave a greater CTL immune response than the WT, ILKEPVHGVY. The mechanism of this action was related to a lower expression of HLA-Cw*1202 on the surface of the presenting cells, thus diminishing KIR2DL2 recognition, and resulting in greater NK cell activation.

References

Lin2016 Zhansong Lin, Kimiko Kuroki, Nozomi Kuse, Xiaoming Sun, Tomohiro Akahoshi, Ying Qi, Takayuki Chikata, Takuya Naruto, Madoka Koyanagi, Hayato Murakoshi, Hiroyuki Gatanaga, Shinichi Oka, Mary Carrington, Katsumi Maenaka, and Masafumi Takiguchi. HIV-1 Control by NK Cells via Reduced Interaction between KIR2DL2 and HLA-C*12:02/C*14:03. Cell Rep., 17(9):2210-2220, 22 Nov 2016. PubMed ID: 27880898. Show all entries for this paper.