HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 61910

HXB2 Location  Pol(464-473)   Pol Epitope Map
View variants at this location
Epitope ILKEPVHGVY   Epitope Alignment
ILKEPVHGaY   altered KIR binding or increased/decreased off-rate
Epitope Name Pol IY10
Species (MHC/HLA human(C*12:02)

Variant Details

Showing all: 1 variant(s).

Variant ID.  4128
Epitope Seq.  ILKEPVHGVY
Variant Seq.  ILKEPVHGaY
Mutations V/A
Epitope Location V9A
HXB2 Location V472A
Mutation Type AKB: altered KIR binding or increased/decreased off-rate
Method CTL suppression of replication, HLA binding, Other
Note The 9A mutant, ILKEPVHGaY, gave a greater CTL immune response than the WT, ILKEPVHGVY. The mechanism of this action was related to a lower expression of HLA-Cw*1202 on the surface of the presenting cells, thus diminishing KIR2DL2 recognition, and resulting in greater NK cell activation.


Lin2016 Zhansong Lin, Kimiko Kuroki, Nozomi Kuse, Xiaoming Sun, Tomohiro Akahoshi, Ying Qi, Takayuki Chikata, Takuya Naruto, Madoka Koyanagi, Hayato Murakoshi, Hiroyuki Gatanaga, Shinichi Oka, Mary Carrington, Katsumi Maenaka, and Masafumi Takiguchi. HIV-1 Control by NK Cells via Reduced Interaction between KIR2DL2 and HLA-C*12:02/C*14:03. Cell Rep., 17(9):2210-2220, 22 Nov 2016. PubMed ID: 27880898. Show all entries for this paper.

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