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Displaying record number 61889

HXB2 Location  Nef(71-81)   Nef Epitope Map
View variants at this location
Epitope RPQVPLRPMTY   Epitope Alignment
Variants
RPQVPLRPMTf   observed variant; replicative capacity is not abrogated
kPQVPLRPMTY   observed variant; replicative capacity is not abrogated
RPQVPLRPMdY   observed variant; replicative capacity is not abrogated
Epitope Name RY11
Species (MHC/HLA human(B*3501)

Variant Details

Showing all: 3 variant(s).


Variant ID.  4121
Epitope Seq.  RPQVPLRPMTY
Variant Seq.  RPQVPLRPMTf
Mutations Y/F
Epitope Location Y11F
HXB2 Location Y81F
Mutation Type OV: observed variant
RCOK: replicative capacity is not abrogated
Epitope Subtype B
Variant Subtype B
Method CTL suppression of replication, Intracellular cytokine staining, Tetramer binding
Note Nef Y81F, an HLA-B*3501-associated polymorphism is in the NefRY11 epitope, and is not found with any significant difference in pVL, indicating that it has little impact on the suppression of HIV-1 by RY11-specific CTLs.


Variant ID.  4122
Epitope Seq.  RPQVPLRPMTY
Variant Seq.  kPQVPLRPMTY
Mutations R/K
Epitope Location R1K
HXB2 Location R71K
Mutation Type OV: observed variant
RCOK: replicative capacity is not abrogated
Epitope Subtype B
Variant Subtype B
Method CTL suppression of replication, Intracellular cytokine staining, Tetramer binding
Note Nef R71K, an HLA-Cw*0702-associated polymorphism is in the NefRY11 epitope, and did not accumulate in HLA-B*3501+ Japanese individuals. This mutation is selected by Cw*0702-restricted CTL and did not influence control of HIV-1 by B*3501-specific CTL.


Variant ID.  4123
Epitope Seq.  RPQVPLRPMTY
Variant Seq.  RPQVPLRPMdY
Mutations T/D
Epitope Location T10D
HXB2 Location T80D
Mutation Type OV: observed variant
RCOK: replicative capacity is not abrogated
Epitope Subtype B
Variant Subtype B
Method CTL suppression of replication, Intracellular cytokine staining, Tetramer binding
Note Nef T80D, an HLA-A*1101-associated polymorphism is in the NefRY11 epitope, and did not accumulate in HLA-B*3501+ Japanese individuals. This mutation is selected by A*1101-restricted CTL and did not influence control of HIV-1 by B*3501-specific CTL.

References

Murakoshi2018a Hayato Murakoshi, Madoka Koyanagi, Tomohiro Akahoshi, Takayuki Chikata, Nozomi Kuse, Hiroyuki Gatanaga, Sarah L. Rowland-Jones, Shinichi Oka, and Masafumi Takiguchi. Impact of a Single HLA-A*24:02-Associated Escape Mutation on the Detrimental Effect of HLA-B*35:01 in HIV-1 Control. EBioMedicine, 36:103-112, Oct 2018. PubMed ID: 30249546. Show all entries for this paper.


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