Found 1 matching record:
HXB2 Location | Pol(799-808) | Pol Epitope Map
View variants at this location |
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Epitope |
IEAEVIPAET
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Epitope Alignment | ||||||||||
Variants |
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Epitope Name | Pol IT10 | |||||||||||
Species (MHC/HLA) | human(B*40:06) |
Showing all: 3 variant(s).
Variant ID. | 4111 |
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Epitope Seq. | IEAEVIPAET |
Variant Seq. | mEAEVIPAET |
Mutations | I/M |
Epitope Location | I1M |
HXB2 Location | I799M |
Mutation Type | OV: observed variant SF: susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | Intracellular cytokine staining, Other |
Note | mEAEVIPAET, IT10-1M is a variant of B*4006-restricted WT epitope IEAEVIPAET. It is cross-recognized by IT10-specific CTL, and is found in 10.5% chronically HIV-1-infected Japanese patients and 10.3% of those patients that are B*4006+. |
Variant ID. | 4112 |
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Epitope Seq. | IEAEVIPAET |
Variant Seq. | lEAEVIPAET |
Mutations | I/L |
Epitope Location | I1L |
HXB2 Location | I799L |
Mutation Type | OV: observed variant SF: susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | Intracellular cytokine staining, Other |
Note | lEAEVIPAET, IT10-1L is a variant of B*4006-restricted WT epitope IEAEVIPAET. It is cross-recognized by IT10-specific CTL, and is found in 2% chronically HIV-1-infected Japanese patients and 10.3% of those patients that are B*4006+. |
Variant ID. | 4113 |
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Epitope Seq. | IEAEVIPAET |
Variant Seq. | IEAEVIsAET |
Mutations | P/S |
Epitope Location | P7S |
HXB2 Location | P805S |
Mutation Type | NSF: non-susceptible form OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Method | Intracellular cytokine staining, Other |
Note | IEAEVIsAET, IT10-7S is a variant of B*4006-restricted WT epitope IEAEVIPAET. It is not recognized by IT10-specific CTL, and is found in 0.7% chronically HIV-1-infected Japanese patients and 3.4% of those patients that are B*4006+. |
Murakoshi2019 Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Yu Zhang, Takayuki Chikata, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, Keiko Sakai, and Masafumi Takiguchi. Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30333175. Show all entries for this paper.
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