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Found 1 matching record:

Displaying record number 61886

HXB2 Location  Pol(799-808)   Pol Epitope Map
View variants at this location
Epitope IEAEVIPAET   Epitope Alignment
Variants
mEAEVIPAET   observed variant; susceptible form
lEAEVIPAET   observed variant; susceptible form
IEAEVIsAET   non-susceptible form; observed variant
Epitope Name Pol IT10
Species (MHC/HLA human(B*4006)

Variant Details

Showing all: 3 variant(s).


Variant ID.  4111
Epitope Seq.  IEAEVIPAET
Variant Seq.  mEAEVIPAET
Mutations I/M
Epitope Location I1M
HXB2 Location I799M
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note mEAEVIPAET, IT10-1M is a variant of B*4006-restricted WT epitope IEAEVIPAET. It is cross-recognized by IT10-specific CTL, and is found in 10.5% chronically HIV-1-infected Japanese patients and 10.3% of those patients that are B*4006+.


Variant ID.  4112
Epitope Seq.  IEAEVIPAET
Variant Seq.  lEAEVIPAET
Mutations I/L
Epitope Location I1L
HXB2 Location I799L
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note lEAEVIPAET, IT10-1L is a variant of B*4006-restricted WT epitope IEAEVIPAET. It is cross-recognized by IT10-specific CTL, and is found in 2% chronically HIV-1-infected Japanese patients and 10.3% of those patients that are B*4006+.


Variant ID.  4113
Epitope Seq.  IEAEVIPAET
Variant Seq.  IEAEVIsAET
Mutations P/S
Epitope Location P7S
HXB2 Location P805S
Mutation Type NSF: non-susceptible form
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note IEAEVIsAET, IT10-7S is a variant of B*4006-restricted WT epitope IEAEVIPAET. It is not recognized by IT10-specific CTL, and is found in 0.7% chronically HIV-1-infected Japanese patients and 3.4% of those patients that are B*4006+.

References

Murakoshi2019 Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Yu Zhang, Takayuki Chikata, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, Keiko Sakai, and Masafumi Takiguchi. Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30333175. Show all entries for this paper.


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