HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Pol(783-791) | Pol Epitope Map
View variants at this location |
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| Epitope |
LEGKIILVA
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Epitope Alignment | |||||||||||||
| Variants |
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| Epitope Name | Pol LA9 | ||||||||||||||
| Species (MHC/HLA) | human(B*40:06) | ||||||||||||||
Showing all: 4 variant(s).
| Variant ID. | 4107 |
|---|---|
| Epitope Seq. | LEGKIILVA |
| Variant Seq. | LEGKvILVA |
| Mutations | I/V |
| Epitope Location | I5V |
| HXB2 Location | I787V |
| Mutation Type | OV: observed variant SF: susceptible form |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Intracellular cytokine staining, Other |
| Note | LEGKvILVA, LA9-5V is a variant of B*4006-restricted WT epitope LEGKIILVA. It is cross-recognized by LA9-specific CTL, and is found in 15.3% chronically HIV-1-infected Japanese patients and 10% of those that are B*4006+. |
| Variant ID. | 4108 |
|---|---|
| Epitope Seq. | LEGKIILVA |
| Variant Seq. | LEGKIIiVA |
| Mutations | L/I |
| Epitope Location | L7I |
| HXB2 Location | L789I |
| Mutation Type | OV: observed variant SF: susceptible form |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Intracellular cytokine staining, Other |
| Note | LEGKIIiVA, LA9-7I is a variant of B*4006-restricted WT epitope LEGKIILVA. It is cross-recognized by LA9-specific CTL, and is found in 6.1% chronically HIV-1-infected Japanese patients but none of those that are B*4006+. |
| Variant ID. | 4109 |
|---|---|
| Epitope Seq. | LEGKIILVA |
| Variant Seq. | LEGKvImVA |
| Mutations | I/V L/M |
| Epitope Location | I5V L7M |
| HXB2 Location | I787V L789M |
| Mutation Type | OV: observed variant SF: susceptible form |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Intracellular cytokine staining, Other |
| Note | LEGKvImVA, LA9-5V7M is a variant of B*4006-restricted WT epitope LEGKIILVA. It is cross-recognized by LA9-specific CTL, and is found in 0.7% chronically HIV-1-infected Japanese patients but none of those that are B*4006+. |
| Variant ID. | 4110 |
|---|---|
| Epitope Seq. | LEGKIILVA |
| Variant Seq. | LEGqIILVA |
| Mutations | K/Q |
| Epitope Location | K4Q |
| HXB2 Location | K786Q |
| Mutation Type | NSF: non-susceptible form OV: observed variant |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Intracellular cytokine staining, Other |
| Note | LEGqIILVA, LA9-4Q is a variant of B*4006-restricted WT epitope LEGKIILVA. It is not recognized by LA9-specific CTL, and is found in 1% chronically HIV-1-infected Japanese patients but none of those that are B*4006+. |
Murakoshi2019 Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Yu Zhang, Takayuki Chikata, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, Keiko Sakai, and Masafumi Takiguchi. Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30333175. Show all entries for this paper.