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Displaying record number 61885

HXB2 Location  Pol(783-791)   Pol Epitope Map
View variants at this location
Epitope LEGKIILVA   Epitope Alignment
Variants
LEGKvILVA   observed variant; susceptible form
LEGKIIiVA   observed variant; susceptible form
LEGKvImVA   observed variant; susceptible form
LEGqIILVA   non-susceptible form; observed variant
Epitope Name Pol LA9
Species (MHC/HLA human(B*40:06)

Variant Details

Showing all: 4 variant(s).


Variant ID.  4107
Epitope Seq.  LEGKIILVA
Variant Seq.  LEGKvILVA
Mutations I/V
Epitope Location I5V
HXB2 Location I787V
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note LEGKvILVA, LA9-5V is a variant of B*4006-restricted WT epitope LEGKIILVA. It is cross-recognized by LA9-specific CTL, and is found in 15.3% chronically HIV-1-infected Japanese patients and 10% of those that are B*4006+.


Variant ID.  4108
Epitope Seq.  LEGKIILVA
Variant Seq.  LEGKIIiVA
Mutations L/I
Epitope Location L7I
HXB2 Location L789I
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note LEGKIIiVA, LA9-7I is a variant of B*4006-restricted WT epitope LEGKIILVA. It is cross-recognized by LA9-specific CTL, and is found in 6.1% chronically HIV-1-infected Japanese patients but none of those that are B*4006+.


Variant ID.  4109
Epitope Seq.  LEGKIILVA
Variant Seq.  LEGKvImVA
Mutations I/V L/M
Epitope Location I5V L7M
HXB2 Location I787V L789M
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note LEGKvImVA, LA9-5V7M is a variant of B*4006-restricted WT epitope LEGKIILVA. It is cross-recognized by LA9-specific CTL, and is found in 0.7% chronically HIV-1-infected Japanese patients but none of those that are B*4006+.


Variant ID.  4110
Epitope Seq.  LEGKIILVA
Variant Seq.  LEGqIILVA
Mutations K/Q
Epitope Location K4Q
HXB2 Location K786Q
Mutation Type NSF: non-susceptible form
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note LEGqIILVA, LA9-4Q is a variant of B*4006-restricted WT epitope LEGKIILVA. It is not recognized by LA9-specific CTL, and is found in 1% chronically HIV-1-infected Japanese patients but none of those that are B*4006+.

References

Murakoshi2019 Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Yu Zhang, Takayuki Chikata, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, Keiko Sakai, and Masafumi Takiguchi. Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30333175. Show all entries for this paper.


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