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Displaying record number 61884

HXB2 Location  Pol(423-431)   Pol Epitope Map
View variants at this location
Epitope SQIYAGIKV   Epitope Alignment
Variants
SQIYpGIKV   observed variant; susceptible form
SQIYpGIKi   observed variant; susceptible form
SQIYsGIKV   observed variant; susceptible form
SQIYpGvKV   observed variant; susceptible form
SQIYpGIrV   observed variant; susceptible form
SQIYpGIri   observed variant; susceptible form
SQIYtGIKV   observed variant; susceptible form
Epitope Name Pol SV9
Species (MHC/HLA human(A*02:06)

Variant Details

Showing all: 7 variant(s).


Variant ID.  4100
Epitope Seq.  SQIYAGIKV
Variant Seq.  SQIYpGIKV
Mutations A/P
Epitope Location A5P
HXB2 Location A427P
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note SQIYpGIKV, SV9-5P is a variant of A*0206-restricted WT epitope SQIYAGIKV. It is cross-recognized by SV9-specific CTL, and is found in 48.1% chronically HIV-1-infected Japanese patients and 14% of those that are A*0206+; which is a greater percentage than WT SV9.


Variant ID.  4101
Epitope Seq.  SQIYAGIKV
Variant Seq.  SQIYpGIKi
Mutations A/P V/I
Epitope Location A5P V9I
HXB2 Location A427P V431I
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note SQIYpGIKi, SV9-5P9I is a variant of A*0206-restricted WT epitope SQIYAGIKV. It is cross-recognized by SV9-specific CTL, and is found in 14.9% chronically HIV-1-infected Japanese patients and 43.9% of those that are A*0206+.


Variant ID.  4102
Epitope Seq.  SQIYAGIKV
Variant Seq.  SQIYsGIKV
Mutations A/S
Epitope Location A5S
HXB2 Location A427S
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note SQIYsGIKV, SV9-5S is a variant of A*0206-restricted WT epitope SQIYAGIKV. It is cross-recognized by SV9-specific CTL, and is found in 9.4% chronically HIV-1-infected Japanese patients and 21.1% of those that are A*0206+.


Variant ID.  4103
Epitope Seq.  SQIYAGIKV
Variant Seq.  SQIYpGvKV
Mutations A/P I/V
Epitope Location A5P I7V
HXB2 Location A427P I429V
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note SQIYpGvKV, SV9-5P7V is a variant of A*0206-restricted WT epitope SQIYAGIKV. It is cross-recognized by SV9-specific CTL, and is found in 2.3% chronically HIV-1-infected Japanese patients and 5.3% of those that are A*0206+.


Variant ID.  4104
Epitope Seq.  SQIYAGIKV
Variant Seq.  SQIYpGIrV
Mutations A/P K/R
Epitope Location A5P K8R
HXB2 Location A427P K430R
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note SQIYpGIrV, SV9-5P8R is a variant of A*0206-restricted WT epitope SQIYAGIKV. It is cross-recognized by SV9-specific CTL, and is found in 1.3% chronically HIV-1-infected Japanese patients and 5.3% of those that are A*0206+.


Variant ID.  4105
Epitope Seq.  SQIYAGIKV
Variant Seq.  SQIYpGIri
Mutations A/P K/R V/I
Epitope Location A5P K8R V9I
HXB2 Location A427P K430R V431I
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note SQIYpGIri, SV9-5P8R9I is a variant of A*0206-restricted WT epitope SQIYAGIKV. It is cross-recognized by SV9-specific CTL, and is found in 1% chronically HIV-1-infected Japanese patients and 1.8% of those that are A*0206+.


Variant ID.  4106
Epitope Seq.  SQIYAGIKV
Variant Seq.  SQIYtGIKV
Mutations A/T
Epitope Location A5T
HXB2 Location A427T
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note SQIYtGIKV, SV9-5T is a variant of A*0206-restricted WT epitope SQIYAGIKV. It is cross-recognized by SV9-specific CTL, and is found in 0.6% chronically HIV-1-infected Japanese patients and in none of the subjects that are A*0206+.

References

Murakoshi2019 Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Yu Zhang, Takayuki Chikata, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, Keiko Sakai, and Masafumi Takiguchi. Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30333175. Show all entries for this paper.


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