HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Pol(423-431) | Pol Epitope Map
View variants at this location |
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| Epitope |
SQIYAGIKV
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Epitope Alignment | ||||||||||||||||||||||
| Variants |
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| Epitope Name | Pol SV9 | |||||||||||||||||||||||
| Species (MHC/HLA) | human(A*02:06) | |||||||||||||||||||||||
Showing all: 7 variant(s).
| Variant ID. | 4100 |
|---|---|
| Epitope Seq. | SQIYAGIKV |
| Variant Seq. | SQIYpGIKV |
| Mutations | A/P |
| Epitope Location | A5P |
| HXB2 Location | A427P |
| Mutation Type | OV: observed variant SF: susceptible form |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Intracellular cytokine staining, Other |
| Note | SQIYpGIKV, SV9-5P is a variant of A*0206-restricted WT epitope SQIYAGIKV. It is cross-recognized by SV9-specific CTL, and is found in 48.1% chronically HIV-1-infected Japanese patients and 14% of those that are A*0206+; which is a greater percentage than WT SV9. |
| Variant ID. | 4101 |
|---|---|
| Epitope Seq. | SQIYAGIKV |
| Variant Seq. | SQIYpGIKi |
| Mutations | A/P V/I |
| Epitope Location | A5P V9I |
| HXB2 Location | A427P V431I |
| Mutation Type | OV: observed variant SF: susceptible form |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Intracellular cytokine staining, Other |
| Note | SQIYpGIKi, SV9-5P9I is a variant of A*0206-restricted WT epitope SQIYAGIKV. It is cross-recognized by SV9-specific CTL, and is found in 14.9% chronically HIV-1-infected Japanese patients and 43.9% of those that are A*0206+. |
| Variant ID. | 4102 |
|---|---|
| Epitope Seq. | SQIYAGIKV |
| Variant Seq. | SQIYsGIKV |
| Mutations | A/S |
| Epitope Location | A5S |
| HXB2 Location | A427S |
| Mutation Type | OV: observed variant SF: susceptible form |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Intracellular cytokine staining, Other |
| Note | SQIYsGIKV, SV9-5S is a variant of A*0206-restricted WT epitope SQIYAGIKV. It is cross-recognized by SV9-specific CTL, and is found in 9.4% chronically HIV-1-infected Japanese patients and 21.1% of those that are A*0206+. |
| Variant ID. | 4103 |
|---|---|
| Epitope Seq. | SQIYAGIKV |
| Variant Seq. | SQIYpGvKV |
| Mutations | A/P I/V |
| Epitope Location | A5P I7V |
| HXB2 Location | A427P I429V |
| Mutation Type | OV: observed variant SF: susceptible form |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Intracellular cytokine staining, Other |
| Note | SQIYpGvKV, SV9-5P7V is a variant of A*0206-restricted WT epitope SQIYAGIKV. It is cross-recognized by SV9-specific CTL, and is found in 2.3% chronically HIV-1-infected Japanese patients and 5.3% of those that are A*0206+. |
| Variant ID. | 4104 |
|---|---|
| Epitope Seq. | SQIYAGIKV |
| Variant Seq. | SQIYpGIrV |
| Mutations | A/P K/R |
| Epitope Location | A5P K8R |
| HXB2 Location | A427P K430R |
| Mutation Type | OV: observed variant SF: susceptible form |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Intracellular cytokine staining, Other |
| Note | SQIYpGIrV, SV9-5P8R is a variant of A*0206-restricted WT epitope SQIYAGIKV. It is cross-recognized by SV9-specific CTL, and is found in 1.3% chronically HIV-1-infected Japanese patients and 5.3% of those that are A*0206+. |
| Variant ID. | 4105 |
|---|---|
| Epitope Seq. | SQIYAGIKV |
| Variant Seq. | SQIYpGIri |
| Mutations | A/P K/R V/I |
| Epitope Location | A5P K8R V9I |
| HXB2 Location | A427P K430R V431I |
| Mutation Type | OV: observed variant SF: susceptible form |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Intracellular cytokine staining, Other |
| Note | SQIYpGIri, SV9-5P8R9I is a variant of A*0206-restricted WT epitope SQIYAGIKV. It is cross-recognized by SV9-specific CTL, and is found in 1% chronically HIV-1-infected Japanese patients and 1.8% of those that are A*0206+. |
| Variant ID. | 4106 |
|---|---|
| Epitope Seq. | SQIYAGIKV |
| Variant Seq. | SQIYtGIKV |
| Mutations | A/T |
| Epitope Location | A5T |
| HXB2 Location | A427T |
| Mutation Type | OV: observed variant SF: susceptible form |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Intracellular cytokine staining, Other |
| Note | SQIYtGIKV, SV9-5T is a variant of A*0206-restricted WT epitope SQIYAGIKV. It is cross-recognized by SV9-specific CTL, and is found in 0.6% chronically HIV-1-infected Japanese patients and in none of the subjects that are A*0206+. |
Murakoshi2019 Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Yu Zhang, Takayuki Chikata, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, Keiko Sakai, and Masafumi Takiguchi. Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30333175. Show all entries for this paper.