HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 61679

HXB2 Location  Nef(82-91)   Nef Epitope Map
View variants at this location
Epitope KAAFDLSFFL   Epitope Alignment
KgAFDLSFFL   HLA association
Epitope Name Nef-KL10
Species (MHC/HLA human(B*57:02, B*57:03, B*58:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.  4074
Epitope Seq.  KAAFDLSFFL
Variant Seq.  KgAFDLSFFL
Mutations A/G
Epitope Location A2G
HXB2 Location A83G
Mutation Type A: HLA association
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy
Note HLA-associated escape, KgAFDLSFFL, was more significantly associated with HLA-B*5801 than with B*5703.


Carlson2012 Jonathan M. Carlson, Jennifer Listgarten, Nico Pfeifer, Vincent Tan, Carl Kadie, Bruce D. Walker, Thumbi Ndung'u, Roger Shapiro, John Frater, Zabrina L. Brumme, Philip J. R. Goulder, and David Heckerman. Widespread Impact of HLA Restriction on Immune Control and Escape Pathways of HIV-1. J. Virol., 86(9):5230-5243, May 2012. PubMed ID: 22379086. Show all entries for this paper.

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