Found 1 matching record:
HXB2 Location | Gag(240-249) | Gag Epitope Map
View variants at this location |
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Epitope |
TSTLQEQIGW
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Epitope Alignment | ||||
Variants |
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Epitope Name | TW10 | |||||
Species (MHC/HLA) | human(B*57:03) |
Showing all: 1 variant(s).
Variant ID. | 4022 |
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Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSnLQEQIGW |
Mutations | T/N |
Epitope Location | T3N |
HXB2 Location | T242N |
Mutation Type | A: HLA association LE: literature escape OV: observed variant SNSF: subtype-specific non-susceptible form |
Epitope Subtype | B, C |
Variant Subtype | B, C |
Method | Sequence |
Note | Polymorphism at T242N, for escape TSnLQEQIGW, was associated with HLA-B*5703 in B-infected subjects of the Barbados cohort. There are no observable clade-specific differences between C-clade (Botswana) and B-clade 242N. |
Payne2014 R. P. Payne, S. Branch, H Kløverpris, P. C. Matthews, C. K. Koofhethile, T. Strong, E. Adland, E. Leitman, J. Frater, T. Ndung'u, E. Hunter, R. Haubrich, B. Mothe, A. Edwards, L. Riddell, F. Chen, P. R. Harrigan, Z. L. Brumme, S. Mallal, M. John, J. P. Jooste, R. Shapiro, S. G. Deeks, B. D. Walker, C. Brander, C. Landis, J. M. Carlson, J. G. Prado, and P. J. R. Goulder. Differential Escape Patterns within the Dominant HLA-B*57:03-Restricted HIV Gag Epitope Reflect Distinct Clade-Specific Functional Constraints. J. Virol., 88(9):4668-4678, May 2014. PubMed ID: 24501417. Show all entries for this paper.
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