HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 61629

HXB2 Location  Gag(147-155)   Gag Epitope Map
View variants at this location
Epitope ISPRTLNAW   Epitope Alignment
xSPRTLNAW   HLA association; literature escape; observed variant; subtype-specific non-susceptible form
lSPRTLNAW   literature escape
Epitope Name ISW9
Species (MHC/HLA human(B*57:03)

Variant Details

Showing all: 2 variant(s).

Variant ID.  4021
Epitope Seq.  ISPRTLNAW
Variant Seq.  xSPRTLNAW
Mutations I/X
Epitope Location I1X
HXB2 Location I147X
Mutation Type A: HLA association
LE: literature escape
OV: observed variant
SNSF: subtype-specific non-susceptible form
Epitope Subtype B
Variant Subtype B
Method Sequence
Note Polymorphism at I147X, for escape xSPRTLNAW, was associated with HLA-B*5703 in B-infected subjects of the Barbados cohort.

Variant ID.  4023
Epitope Seq.  ISPRTLNAW
Variant Seq.  lSPRTLNAW
Mutations I/L
Epitope Location I1L
HXB2 Location I147L
Mutation Type LE: literature escape
Epitope Subtype B, C
Variant Subtype B, C
Method Sequence
Note There are no observable clade-specific differences between C-clade (Botswana) and B-clade (Barbados) 147L.


Payne2014 R. P. Payne, S. Branch, H Kløverpris, P. C. Matthews, C. K. Koofhethile, T. Strong, E. Adland, E. Leitman, J. Frater, T. Ndung'u, E. Hunter, R. Haubrich, B. Mothe, A. Edwards, L. Riddell, F. Chen, P. R. Harrigan, Z. L. Brumme, S. Mallal, M. John, J. P. Jooste, R. Shapiro, S. G. Deeks, B. D. Walker, C. Brander, C. Landis, J. M. Carlson, J. G. Prado, and P. J. R. Goulder. Differential Escape Patterns within the Dominant HLA-B*57:03-Restricted HIV Gag Epitope Reflect Distinct Clade-Specific Functional Constraints. J. Virol., 88(9):4668-4678, May 2014. PubMed ID: 24501417. Show all entries for this paper.

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