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Found 1 matching record:

Displaying record number 61523

HXB2 Location  Pol(283-290)   Pol Epitope Map
View variants at this location
Epitope TAFTIPSI   Epitope Alignment
Variants
TAFTIPSt   observed variant
TAFTIPSl   observed variant
TAFTIPSv   observed variant
TAFTIPSr   observed variant
TAFTIPSm   observed variant
Epitope Name Pol283-8, TI8
Species (MHC/HLA human(B*51:01, B*52:01)

Variant Details

Showing all: 5 variant(s).


Variant ID.  3948
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSt
Mutations I/T
Epitope Location I8T
HXB2 Location I290T
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other, Relative replication capacity assay, Tetramer binding
Note I135T is strongly associated with HLA-B*5101 but weakly associated with HLA-B*5201 in both Japanese and Caucasian cohorts.


Variant ID.  3949
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSl
Mutations I/L
Epitope Location I8L
HXB2 Location I290L
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note I135L is weakly associated with HLA-B*5101 and HLA-B*5201 in Japanese cohorts, but is not associated with either allele in Caucasian cohorts.


Variant ID.  3950
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSv
Mutations I/V
Epitope Location I8V
HXB2 Location I290V
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note I135V is weakly associated with HLA-B*5101 and HLA-B*5201 in Japanese cohorts, but is not associated with B*5101 in Caucasian cohorts. Association between B*5201 and I135V is weak but present in Caucasians studied.


Variant ID.  3951
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSr
Mutations I/R
Epitope Location I8R
HXB2 Location I290R
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note I135R is not associated with HLA-B*5101 or -B*5201 in either Japanese or Caucasian cohorts.


Variant ID.  3952
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSm
Mutations I/M
Epitope Location I8M
HXB2 Location I290M
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note I135M is not associated with HLA-B*5101 or -B*5201 in either Japanese or Caucasian cohorts.

References

Yagita2013 Yuichi Yagita, Nozomi Kuse, Kimiko Kuroki, Hiroyuki Gatanaga, Jonathan M. Carlson, Takayuki Chikata, Zabrina L. Brumme, Hayato Murakoshi, Tomohiro Akahoshi, Nico Pfeifer, Simon Mallal, Mina John, Toyoyuki Ose, Haruki Matsubara, Ryo Kanda, Yuko Fukunaga, Kazutaka Honda, Yuka Kawashima, Yasuo Ariumi, Shinichi Oka, Katsumi Maenaka, and Masafumi Takiguchi. Distinct HIV-1 Escape Patterns Selected by Cytotoxic T Cells with Identical Epitope Specificity. J. Virol., 87(4):2253-2263, Feb 2013. PubMed ID: 23236061. Show all entries for this paper.


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