HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Pol(283-290) | Pol Epitope Map
View variants at this location |
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| Epitope |
TAFTIPSI
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Epitope Alignment | ||||||||||||||||
| Variants |
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| Epitope Name | Pol283-8, TI8 | |||||||||||||||||
| Species (MHC/HLA) | human(B*51:01, B*52:01) | |||||||||||||||||
Showing all: 5 variant(s).
| Variant ID. | 3948 |
|---|---|
| Epitope Seq. | TAFTIPSI |
| Variant Seq. | TAFTIPSt |
| Mutations | I/T |
| Epitope Location | I8T |
| HXB2 Location | I290T |
| Mutation Type | OV: observed variant |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Intracellular cytokine staining, Other, Relative replication capacity assay, Tetramer binding |
| Note | I135T is strongly associated with HLA-B*5101 but weakly associated with HLA-B*5201 in both Japanese and Caucasian cohorts. |
| Variant ID. | 3949 |
|---|---|
| Epitope Seq. | TAFTIPSI |
| Variant Seq. | TAFTIPSl |
| Mutations | I/L |
| Epitope Location | I8L |
| HXB2 Location | I290L |
| Mutation Type | OV: observed variant |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Sequence |
| Note | I135L is weakly associated with HLA-B*5101 and HLA-B*5201 in Japanese cohorts, but is not associated with either allele in Caucasian cohorts. |
| Variant ID. | 3950 |
|---|---|
| Epitope Seq. | TAFTIPSI |
| Variant Seq. | TAFTIPSv |
| Mutations | I/V |
| Epitope Location | I8V |
| HXB2 Location | I290V |
| Mutation Type | OV: observed variant |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Sequence |
| Note | I135V is weakly associated with HLA-B*5101 and HLA-B*5201 in Japanese cohorts, but is not associated with B*5101 in Caucasian cohorts. Association between B*5201 and I135V is weak but present in Caucasians studied. |
| Variant ID. | 3951 |
|---|---|
| Epitope Seq. | TAFTIPSI |
| Variant Seq. | TAFTIPSr |
| Mutations | I/R |
| Epitope Location | I8R |
| HXB2 Location | I290R |
| Mutation Type | OV: observed variant |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Sequence |
| Note | I135R is not associated with HLA-B*5101 or -B*5201 in either Japanese or Caucasian cohorts. |
| Variant ID. | 3952 |
|---|---|
| Epitope Seq. | TAFTIPSI |
| Variant Seq. | TAFTIPSm |
| Mutations | I/M |
| Epitope Location | I8M |
| HXB2 Location | I290M |
| Mutation Type | OV: observed variant |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | Sequence |
| Note | I135M is not associated with HLA-B*5101 or -B*5201 in either Japanese or Caucasian cohorts. |
Yagita2013 Yuichi Yagita, Nozomi Kuse, Kimiko Kuroki, Hiroyuki Gatanaga, Jonathan M. Carlson, Takayuki Chikata, Zabrina L. Brumme, Hayato Murakoshi, Tomohiro Akahoshi, Nico Pfeifer, Simon Mallal, Mina John, Toyoyuki Ose, Haruki Matsubara, Ryo Kanda, Yuko Fukunaga, Kazutaka Honda, Yuka Kawashima, Yasuo Ariumi, Shinichi Oka, Katsumi Maenaka, and Masafumi Takiguchi. Distinct HIV-1 Escape Patterns Selected by Cytotoxic T Cells with Identical Epitope Specificity. J. Virol., 87(4):2253-2263, Feb 2013. PubMed ID: 23236061. Show all entries for this paper.