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Found 1 matching record:

Displaying record number 61519

HXB2 Location  Pol(928-935)   Pol Epitope Map
View variants at this location
Epitope LQKQITKI   Epitope Alignment
Variants
LQKQIsKI   diminished HLA binding or increased off-rate; observed variant
LQKQITKl   diminished HLA binding or increased off-rate; observed variant
Epitope Name LI8
Species (MHC/HLA human(B*52:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3922
Epitope Seq.  LQKQITKI
Variant Seq.  LQKQIsKI
Mutations T/S
Epitope Location T6S
HXB2 Location T933S
Mutation Type DHB: diminished HLA binding or increased off-rate
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note Variant LQKQIsKI (6S) is weakly recognized by B*5201-restricted-CTL. Mutant viruses with the same mutation (NL-935L) show significantly reduced recognition by LI8-specific CTL, suggesting the mutation was LI8-specific CTL-selected. This mutation affects replication competence of the virus.


Variant ID.  3923
Epitope Seq.  LQKQITKI
Variant Seq.  LQKQITKl
Mutations I/L
Epitope Location I8L
HXB2 Location I935L
Mutation Type DHB: diminished HLA binding or increased off-rate
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note Variant LQKQITKl (8L) is weakly recognized by B*5201-restricted-CTL. Mutant viruses with the same mutation (NL-935L) fail to be recognized by LI8-specific CTL, suggesting the mutation was LI8-specific CTL-selected. This mutation affects replication competence of the virus.

References

Murakoshi2017 Hayato Murakoshi, Madoka Koyanagi, Takayuki Chikata, Mohammad Arif Rahman, Nozomi Kuse, Keiko Sakai, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Accumulation of Pol Mutations Selected by HLA-B*52:01-C*12:02 Protective Haplotype-Restricted Cytotoxic T Lymphocytes Causes Low Plasma Viral Load Due to Low Viral Fitness of Mutant Viruses. J. Virol., 91(4), 15 Feb 2017. PubMed ID: 27903797. Show all entries for this paper.


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