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Found 1 matching record:

Displaying record number 61513

HXB2 Location  Pol(783-791)   Pol Epitope Map
View variants at this location
Epitope LEGKIILVA   Epitope Alignment
Variants
LEGKvILVA   observed variant
Epitope Name PolLA9
Species (MHC/HLA human(B*40:06)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3917
Epitope Seq.  LEGKIILVA
Variant Seq.  LEGKvILVA
Mutations I/V
Epitope Location I5V
HXB2 Location I787V
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note Pol LEGKIILVA variant, LEGKvILVA (5V) was seen at 35.6% in sequences from the Los Alamos database, but at 15.3% in this Japanese cohort. LA9-5V and LA9 were cross-recognized in 3/4 HLA-A*0206 subjects - KI-763, KI-912, KI-928 and KI-756.

References

Murakoshi2015 Hayato Murakoshi, Tomohiro Akahoshi, Madoka Koyanagi, Takayuki Chikata, Takuya Naruto, Rie Maruyama, Yoshiko Tamura, Naoki Ishizuka, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Clinical Control of HIV-1 by Cytotoxic T Cells Specific for Multiple Conserved Epitopes. J. Virol., 89(10):5330-5339, May 2015. PubMed ID: 25741000. Show all entries for this paper.


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