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Displaying record number 61512

HXB2 Location Pol(423-431) Pol Epitope Map
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SQIYAGIKV

`SQIYpGIKV`		observed variant
`SQIYpGIKi`		observed variant
`SQIYsGIKV`		observed variant

Epitope Name PolSV9

Species (MHC/HLA) human(A*02:06)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`3914`
Epitope Seq.	`SQIYAGIKV`
Variant Seq.	`SQIYpGIKV`
Mutations	A/P
Epitope Location	A5P
HXB2 Location	A427P
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	Sequence
Note	Pol SQIYAGIKV variant, 5P, SQIYpGIKV, was seen at 37.5% in sequences from the Los Alamos database, but at 47.7% in this Japanese cohort. Variant PolSV9-5P and another variant, SV9-5P9I were cross-recognized in 3/4 HLA-A*0206 subjects - KI-763, KI-912, KI-926 but not KI-643.

Variant ID.	`3915`
Epitope Seq.	`SQIYAGIKV`
Variant Seq.	`SQIYpGIKi`
Mutations	A/P V/I
Epitope Location	A5P V9I
HXB2 Location	A427P V431I
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	Sequence
Note	Pol SQIYAGIKV variant, SQIYpGIKi (5P9I), was seen at 2.4% in sequences from the Los Alamos database, but at 14.8% in this Japanese cohort. PolSV9-5P9I and another variant, SV9-5P were cross-recognized in 3/4 HLA-A*0206 subjects - KI-763, KI-912, KI-926 but not KI-643.

Variant ID.	`3916`
Epitope Seq.	`SQIYAGIKV`
Variant Seq.	`SQIYsGIKV`
Mutations	A/S
Epitope Location	A5S
HXB2 Location	A427S
Mutation Type	OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	Sequence
Note	Pol SV9 SQIYAGIKV variant, SQIYsGIKV, was seen at 3.7% in sequences from the Los Alamos database, but at 9.4% in this Japanese cohort.

References

Murakoshi2015 Hayato Murakoshi, Tomohiro Akahoshi, Madoka Koyanagi, Takayuki Chikata, Takuya Naruto, Rie Maruyama, Yoshiko Tamura, Naoki Ishizuka, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Clinical Control of HIV-1 by Cytotoxic T Cells Specific for Multiple Conserved Epitopes. J. Virol., 89(10):5330-5339, May 2015. PubMed ID: 25741000. Show all entries for this paper.