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Found 1 matching record:

Displaying record number 61512

HXB2 Location  Pol(423-431)   Pol Epitope Map
View variants at this location
Epitope SQIYAGIKV   Epitope Alignment
Variants
SQIYpGIKV   observed variant
SQIYpGIKi   observed variant
SQIYsGIKV   observed variant
Epitope Name PolSV9
Species (MHC/HLA human(A*02:06)

Variant Details

Showing all: 3 variant(s).


Variant ID.  3914
Epitope Seq.  SQIYAGIKV
Variant Seq.  SQIYpGIKV
Mutations A/P
Epitope Location A5P
HXB2 Location A427P
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note Pol SQIYAGIKV variant, 5P, SQIYpGIKV, was seen at 37.5% in sequences from the Los Alamos database, but at 47.7% in this Japanese cohort. Variant PolSV9-5P and another variant, SV9-5P9I were cross-recognized in 3/4 HLA-A*0206 subjects - KI-763, KI-912, KI-926 but not KI-643.


Variant ID.  3915
Epitope Seq.  SQIYAGIKV
Variant Seq.  SQIYpGIKi
Mutations A/P V/I
Epitope Location A5P V9I
HXB2 Location A427P V431I
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note Pol SQIYAGIKV variant, SQIYpGIKi (5P9I), was seen at 2.4% in sequences from the Los Alamos database, but at 14.8% in this Japanese cohort. PolSV9-5P9I and another variant, SV9-5P were cross-recognized in 3/4 HLA-A*0206 subjects - KI-763, KI-912, KI-926 but not KI-643.


Variant ID.  3916
Epitope Seq.  SQIYAGIKV
Variant Seq.  SQIYsGIKV
Mutations A/S
Epitope Location A5S
HXB2 Location A427S
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note Pol SV9 SQIYAGIKV variant, SQIYsGIKV, was seen at 3.7% in sequences from the Los Alamos database, but at 9.4% in this Japanese cohort.

References

Murakoshi2015 Hayato Murakoshi, Tomohiro Akahoshi, Madoka Koyanagi, Takayuki Chikata, Takuya Naruto, Rie Maruyama, Yoshiko Tamura, Naoki Ishizuka, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Clinical Control of HIV-1 by Cytotoxic T Cells Specific for Multiple Conserved Epitopes. J. Virol., 89(10):5330-5339, May 2015. PubMed ID: 25741000. Show all entries for this paper.


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