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Found 1 matching record:

Displaying record number 61469

HXB2 Location  Gag(277-285)   Gag Epitope Map
View variants at this location
Epitope YSPVSILDI   Epitope Alignment
Variants
YSPtSILDI   escape documented in this paper
Epitope Name YI9
Species (MHC/HLA human(C*01:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3905
Epitope Seq.  YSPVSILDI
Variant Seq.  YSPtSILDI
Mutations V/T
Epitope Location V4T
HXB2 Location V280T
Mutation Type E: escape documented in this paper
Epitope Subtype CRF01_AE
Variant Subtype CRF01_AE
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other, Sequence
Note Mutant YSPtSILDI, was confirmed as an escape by EliSpot in two HLA-Cw*0102 positive patients as well as YI9-specific T cells.

References

VanTran2016 Giang Van Tran, Takayuki Chikata, Jonathan M. Carlson, Hayato Murakoshi, Dung Hoai Nguyen, Yoshiko Tamura, Tomohiro Akahoshi, Nozomi Kuse, Keiko Sakai, Sachiko Sakai, Kyle Cobarrubias, Shinichi Oka, Zabrina L. Brumme, Kinh Van Nguyen, Masafumi Takiguchi, and NHTD Treatment-Naive Cohort Study Group. A Strong Association of Human Leukocyte Antigen-Associated Pol and Gag Mutations with Clinical Parameters in HIV-1 Subtype A/E Infection. AIDS, 30(5):681-689, 13 Mar 2016. PubMed ID: 26595539. Show all entries for this paper.


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