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Displaying record number 61456

HXB2 Location Nef(174-184) Nef Epitope Map
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EDPEKEVLEWR

`dDPEKEVLvWk`		observed variant
`gDPErEVLqWR`		observed variant
`dDPErEiLvWk`		observed variant
`dDPErEVLqWR`		observed variant
`dDPErEVLvWk`		observed variant
`dDPEKEVLqWR`		observed variant
`dDPErEVLmWk`		observed variant
`dDtEKEVLvWk`		observed variant
`eDPErEVLqWk`		observed variant
`eDPErEVLqWR`		observed variant
`dDPEgEVLqWR`		observed variant
`dDPdgEVLqWR`		observed variant
`EDtEKEVLvWk`		observed variant
`dDlErEVLmWk`		observed variant
`EDPEgEVLqWk`		observed variant
`dDPEKEVLqWk`		observed variant

Epitope Name Nef_174-184

Species (MHC/HLA) human

Variant Details

Showing all: 16 variant(s).

Variant ID.	`3858`
Epitope Seq.	`EDPEKEVLEWR`
Variant Seq.	`dDPEKEVLvWk`
Mutations	E/D E/V
Epitope Location	E1D E9V
HXB2 Location	E174D E182V
Mutation Type	OV: observed variant
Method	Other, Sequence
Note	Epitope dDPEKEVLvWK of epitope Nef_174-184 was the circulating autologous form in acute patient 502-0341 of the STEP trial, as 2/7 HIV-1 sequences. The patient also carried variant forms dDPErEVLvWK and dDPErEiLvWK.

Variant ID.	`3859`
Epitope Seq.	`EDPEKEVLEWR`
Variant Seq.	`gDPErEVLqWR`
Mutations	E/G K/R E/Q
Epitope Location	E1G K5R E9Q
HXB2 Location	E174G K178R E182Q
Mutation Type	OV: observed variant
Method	Other, Sequence
Note	Variant gDPErEVLqWR of epitope Nef_174-184 was seen circulating in acute patient 502-0648 of the STEP trial, in 1/4 HIV-1 sequences. The autologous sequence in this patient was dDPErEVLqWR.

Variant ID.	`3860`
Epitope Seq.	`EDPEKEVLEWR`
Variant Seq.	`dDPErEiLvWk`
Mutations	E/D R/K K/R V/I E/V
Epitope Location	E1D R11K K5R V7I E9V
HXB2 Location	E174D R184K K178R V180I E182V
Mutation Type	OV: observed variant
Method	Other, Sequence
Note	Variant dDPErEiLvWk of epitope Nef_174-184 was seen circulating in acute patient 502-0341 of the STEP trial, in 1/7 HIV-1 sequences. The autologous sequence in this patient was dDPEKEVLvWk. Another variant in this patient was dDPErEVLvWk.

Variant ID.	`3861`
Epitope Seq.	`EDPEKEVLEWR`
Variant Seq.	`dDPErEVLqWR`
Mutations	E/D K/R E/Q
Epitope Location	E1D K5R E9Q
HXB2 Location	E174D K178R E182Q
Mutation Type	OV: observed variant
Method	Other, Sequence
Note	Epitope dDPErEVLqWR of epitope Nef_174-184 was the circulating autologous form in acute patients 502-0648 and 502-0841 of the STEP trial, as 3/4 and 1/4 HIV-1 sequences. The patients also carried other variant forms - gDPErEVLqWR; and eDPErEVLqWR, dDPEgEVLqWR and dDPdgEVLqWR.

Variant ID.	`3862`
Epitope Seq.	`EDPEKEVLEWR`
Variant Seq.	`dDPErEVLvWk`
Mutations	E/D R/K K/R E/V
Epitope Location	E1D R11K K5R E9V
HXB2 Location	E174D R184K K178R E182V
Mutation Type	OV: observed variant
Method	Other, Sequence
Note	Variant dDPErEVLvWk of epitope Nef_174-184 was seen circulating in acute patient 502-0341 of the STEP trial, in 4/7 HIV-1 sequences. The autologous sequence in this patient was dDPEKEVLvWk. Another variant in this patient was dDPErEiLvWk.

Variant ID.	`3863`
Epitope Seq.	`EDPEKEVLEWR`
Variant Seq.	`dDPEKEVLqWR`
Mutations	E/D E/Q
Epitope Location	E1D E9Q
HXB2 Location	E174D E182Q
Mutation Type	OV: observed variant
Method	Other, Sequence
Note	Epitope dDPEkEVLqWR of epitope Nef_174-184 was the circulating autologous form in acute patient 502-0879 of the STEP trial, as 3/5 HIV-1 sequences. The patients also carried another variant form - dDPEkEVLqWk.

Variant ID.	`3864`
Epitope Seq.	`EDPEKEVLEWR`
Variant Seq.	`dDPErEVLmWk`
Mutations	E/D R/K K/R E/M
Epitope Location	E1D R11K K5R E9M
HXB2 Location	E174D R184K K178R E182M
Mutation Type	OV: observed variant
Method	Other, Sequence
Note	Epitope dDPErEVLmWk of epitope Nef_174-184 was the circulating autologous form in acute patient 502-0897 of the STEP trial, as 9/10 HIV-1 sequences. The patients also carried another variant form - dDlErEVLmWk.

Variant ID.	`3865`
Epitope Seq.	`EDPEKEVLEWR`
Variant Seq.	`dDtEKEVLvWk`
Mutations	E/D E/V
Epitope Location	E1D E9V
HXB2 Location	E174D E182V
Mutation Type	OV: observed variant
Method	Other, Sequence
Note	Epitope dDtEKEVLvWk of epitope Nef_174-184 was the circulating autologous form in acute patient 502-1512 of the STEP trial, as 7/11 HIV-1 sequences. The patient also carried variant forms eDtEKEVLvWk.

Variant ID.	`3866`
Epitope Seq.	`EDPEKEVLEWR`
Variant Seq.	`eDPErEVLqWk`
Mutations	E/D E/V
Epitope Location	E1D E9V
HXB2 Location	E174D E182V
Mutation Type	OV: observed variant
Method	Other, Sequence
Note	Epitope eDPErEVLqWk of epitope Nef_174-184 was the circulating autologous form in acute patient 502-2586 of the STEP trial, as 5/6 HIV-1 sequences. The patient also carried variant forms eDPEgEVLqWk.

Variant ID.	`3867`
Epitope Seq.	`EDPEKEVLEWR`
Variant Seq.	`eDPErEVLqWR`
Mutations	K/R E/Q
Epitope Location	K5R E9Q
HXB2 Location	K178R E182Q
Mutation Type	OV: observed variant
Method	Other, Sequence
Note	Variant EDPErEVLqWR of epitope Nef_174-184 was seen circulating in acute patient 502-0841 of the STEP trial, in 1/4 HIV-1 sequences. The autologous sequence in this patient was dDPErEVLqWR. Other variants in this patient were dDPEgEVLqWR and dDPdgEVLqWR.

Variant ID.	`3868`
Epitope Seq.	`EDPEKEVLEWR`
Variant Seq.	`dDPEgEVLqWR`
Mutations	E/D K/G E/Q
Epitope Location	E1D K5G E9Q
HXB2 Location	E174D K178G E182Q
Mutation Type	OV: observed variant
Method	Other, Sequence
Note	Variant dDPEgEVLqWR of epitope Nef_174-184 was seen circulating in acute patient 502-0841 of the STEP trial, in 1/4 HIV-1 sequences. The autologous sequence in this patient was dDPErEVLqWR. Other variants in this patient were EDPErEVLqWR and dDPdgEVLqWR.

Variant ID.	`3869`
Epitope Seq.	`EDPEKEVLEWR`
Variant Seq.	`dDPdgEVLqWR`
Mutations	E/D E/D K/G E/Q
Epitope Location	E1D E4D K5G E9Q
HXB2 Location	E174D E177D K178G E182Q
Mutation Type	OV: observed variant
Method	Other, Sequence
Note	Variant dDPdgEVLqWR of epitope Nef_174-184 was seen circulating in acute patient 502-0841 of the STEP trial, in 1/4 HIV-1 sequences. The autologous sequence in this patient was dDPErEVLqWR. Other variants in this patient were EDPErEVLqWR and dDPEgEVLqWR.

Variant ID.	`3870`
Epitope Seq.	`EDPEKEVLEWR`
Variant Seq.	`EDtEKEVLvWk`
Mutations	R/K P/T E/V
Epitope Location	R11K P3T E9V
HXB2 Location	R184K P176T E182V
Mutation Type	OV: observed variant
Method	Other, Sequence
Note	Variant EDtEKEVLvWk of epitope Nef_174-184 was seen circulating in acute patient 502-1512 of the STEP trial, in 4/11 HIV-1 sequences. The autologous sequence in this patient was dDtEKEVLvWk.

Variant ID.	`3871`
Epitope Seq.	`EDPEKEVLEWR`
Variant Seq.	`dDlErEVLmWk`
Mutations	E/D R/K P/L K/R E/M
Epitope Location	E1D R11K P3L K5R E9M
HXB2 Location	E174D R184K P176L K178R E182M
Mutation Type	OV: observed variant
Method	Other, Sequence
Note	Variant dDlErEVLmWk of epitope Nef_174-184 was seen circulating in acute patient 502-0897 of the STEP trial, in 1/10 HIV-1 sequences. The autologous sequence in this patient was dDPErEVLmWk.

Variant ID.	`3872`
Epitope Seq.	`EDPEKEVLEWR`
Variant Seq.	`EDPEgEVLqWk`
Mutations	R/K K/G E/Q
Epitope Location	R11K K5G E9Q
HXB2 Location	R184K K178G E182Q
Mutation Type	OV: observed variant
Method	Other, Sequence
Note	Variant EDPEgEVLqWk of epitope Nef_174-184 was seen circulating in acute patient 502-2586 of the STEP trial, in 1/6 HIV-1 sequences. The autologous sequence in this patient was EDPErEVLqWk.

Variant ID.	`3873`
Epitope Seq.	`EDPEKEVLEWR`
Variant Seq.	`dDPEKEVLqWk`
Mutations	E/D R/K E/Q
Epitope Location	E1D R11K E9Q
HXB2 Location	E174D R184K E182Q
Mutation Type	OV: observed variant
Method	Other, Sequence
Note	Variant dDPEKEVLqWk of epitope Nef_174-184 was seen circulating in acute patient 502-0879 of the STEP trial, in 2/5 HIV-1 sequences. The autologous sequence in this patient was dDPEKEVLqWR.

References

Park2016a Sung Yong Park, Wendy J Mack, and Ha Y Lee. Enhancement of viral escape in HIV-1 Nef by STEP vaccination. AIDS, 30(16):2449-2458, Oct 23 2016. PubMed ID: 27427874. Show all entries for this paper.