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Displaying record number 61259

HXB2 Location Pol(101-110) Pol Epitope Map
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Epitope

KMIGGVGGFI

Epitope Alignment

Variants

KMIGGiGGFI drug induced; observed variant

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3783`
Epitope Seq.	`KMIGGVGGFI`
Variant Seq.	`KMIGGiGGFI`
Mutations	V/I
Epitope Location	V6I
HXB2 Location	V106I
Mutation Type	DI: drug induced OV: observed variant
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Other, Sequence
Note	The drug induced mutation I50V is seen in several ART-naive patients as epitope KMIGGVGGFI. 11/49 subjects responded to this variant.

References

Blanco-Heredia2016 Juan Blanco-Heredia, Aarón Lecanda, Humberto Valenzuela-Ponce, Christian Brander, Santiago Ávila-Rios, and Gustavo Reyes-Terán. Identification of Immunogenic Cytotoxic T Lymphocyte Epitopes Containing Drug Resistance Mutations in Antiretroviral Treatment-Naive HIV-Infected Individuals. PLoS One, 11(1):e0147571, 2016. PubMed ID: 26808823. Show all entries for this paper.