HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 61238

HXB2 Location  Pol(283-290)   Pol Epitope Map
View variants at this location
Epitope TAFTIPSI   Epitope Alignment
TAFTIPSv   escape documented in this paper
Epitope Name TI8
Species (MHC/HLA human(B*51:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.  3754
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSv
Mutations I/V
Epitope Location I8V
HXB2 Location I290V
Mutation Type E: escape documented in this paper
Epitope Subtype A
Variant Subtype A
Method Other
Note Emergence of mutant I290V, TAFTIPSv, resulted in the deployment of highly crossreactive clonotypes of CTL that recognized wild type TI8 (TAFTIPSI) equally with the TV mutant antigen.


Lissina2016 Anna Lissina, Lisa A. Chakrabarti, Masafumi Takiguchi, and Victor Appay. TCR Clonotypes: Molecular Determinants of T-Cell Efficacy against HIV. Curr. Opin. Virol., 16:77-85, Feb 2016. PubMed ID: 26874617. Show all entries for this paper.

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