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Displaying record number 61237

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KRWIImGLNK   escape documented in this paper
KkWIImGLNK   escape documented in this paper
Epitope Name KK10
Species (MHC/HLA human(B*27:05)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3752
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIImGLNK
Mutations L/M
Epitope Location L6M
HXB2 Location L268M
Mutation Type E: escape documented in this paper
Method Other
Note Escape variant KRWIImGLNK was still recognized by crossreactive clonotypes of CTL that suppressed viral replication of mutants for prolonged times in patients.


Variant ID.  3753
Epitope Seq.  KRWIILGLNK
Variant Seq.  KkWIImGLNK
Mutations R/K L/M
Epitope Location R2K L6M
HXB2 Location R264K L268M
Mutation Type E: escape documented in this paper
Method Other
Note Escape variant KkWIImGLNK, though it does need a compensatory mutation to maintain viral fitness, was successful, not being recognized by crossreactive clonotypes of CTL. This escape evades presentation by HLA-B*2705.

References

Lissina2016 Anna Lissina, Lisa A. Chakrabarti, Masafumi Takiguchi, and Victor Appay. TCR Clonotypes: Molecular Determinants of T-Cell Efficacy against HIV. Curr. Opin. Virol., 16:77-85, Feb 2016. PubMed ID: 26874617. Show all entries for this paper.


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