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Displaying record number 61225

HXB2 Location Nef(106-114) Nef Epitope Map
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Epitope

RQDILDLWI

Epitope Alignment

Variants

RrDILDLWI HLA association; diminished response; escape documented in this paper

Epitope Name RI9

Species (MHC/HLA) human(B*13:02)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3745`
Epitope Seq.	`RQDILDLWI`
Variant Seq.	`RrDILDLWI`
Mutations	Q/R
Epitope Location	Q2R
HXB2 Location	Q107R
Mutation Type	A: HLA association DR: diminished response E: escape documented in this paper
Epitope Subtype	B
Variant Subtype	B
Method	Relative replication capacity assay
Note	Nef mutant RrDILDLWI results in replication reduction. Alongwith another substitution, E24Q, however, it loses the ability to downregulate Class I MHC.

References

Shahid2015 Aniqa Shahid, Alex Olvera, Gursev Anmole, Xiaomei T. Kuang, Laura A. Cotton, Montserrat Plana, Christian Brander, Mark A. Brockman, and Zabrina L. Brumme. Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function. J. Virol., 89(22):11557-11571, Nov 2015. PubMed ID: 26355081. Show all entries for this paper.