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Found 1 matching record:

Displaying record number 61225

HXB2 Location  Nef(106-114)   Nef Epitope Map
View variants at this location
Epitope RQDILDLWI   Epitope Alignment
Variants
RrDILDLWI   HLA association; diminished response; escape documented in this paper
Epitope Name RI9
Species (MHC/HLA human(B*13:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3745
Epitope Seq.  RQDILDLWI
Variant Seq.  RrDILDLWI
Mutations Q/R
Epitope Location Q2R
HXB2 Location Q107R
Mutation Type A: HLA association
DR: diminished response
E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method Relative replication capacity assay
Note Nef mutant RrDILDLWI results in replication reduction. Alongwith another substitution, E24Q, however, it loses the ability to downregulate Class I MHC.

References

Shahid2015 Aniqa Shahid, Alex Olvera, Gursev Anmole, Xiaomei T. Kuang, Laura A. Cotton, Montserrat Plana, Christian Brander, Mark A. Brockman, and Zabrina L. Brumme. Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function. J. Virol., 89(22):11557-11571, Nov 2015. PubMed ID: 26355081. Show all entries for this paper.


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