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HXB2 Location Gag(263-272) Gag Epitope Map
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`KkWIILGLNK`		diminished HLA binding or increased off-rate; diminished response; escape documented in this paper; replicative capacity reduced
`KgWIILGLNK`		diminished HLA binding or increased off-rate; diminished response; escape documented in this paper; replicative capacity reduced
`KtWIILGLNK`		diminished HLA binding or increased off-rate; diminished response; escape documented in this paper; replicative capacity reduced
`KqWIILGLNK`		escape documented in this paper; replicative capacity reduced

Epitope Name KK10

Species (MHC/HLA) human(B*27:05)

Showing all: 4 variant(s).

Variant ID.	`3714`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KkWIILGLNK`
Mutations	R/K
Epitope Location	R2K
HXB2 Location	R264K
Mutation Type	DHB: diminished HLA binding or increased off-rate DR: diminished response E: escape documented in this paper RCR: replicative capacity reduced
Epitope Subtype	B, C
Variant Subtype	B, C
Method	Other
Note	KkWIILGLNK is a late escape variant of KRWIILGLNK at anchor position-2 that reduces VRC substantially and abrogates binding to HLA-B*27. Clade B R264K though associated with progression to AIDS requires compensatory mutation S173A in order for the virus to survive. This mutation invariably follows the less potent but escaping variant, L268X. In Clade C, R264K does not follow L268X and has compensatory mutation S165N. Other compensatory mutations to C clade R264K are found between Protease-217 or Pro-225, PVHAGPIAP, in the cyclophilin A-binding loop.

Variant ID.	`3715`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KgWIILGLNK`
Mutations	R/G
Epitope Location	R2G
HXB2 Location	R264G
Mutation Type	DHB: diminished HLA binding or increased off-rate DR: diminished response E: escape documented in this paper RCR: replicative capacity reduced
Epitope Subtype	B
Variant Subtype	B
Method	Other
Note	KgWIILGLNK is an escape variant of KRWIILGLNK at anchor position-2 that reduces VRC less than R264K does but impairs VRC more than the R264K/S173A combination. Variant R264G does not require compensatory mutation S173A in order for the virus to survive and is typically selected without a preexisting L268X.

Variant ID.	`3716`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KtWIILGLNK`
Mutations	R/T
Epitope Location	R2T
HXB2 Location	R264T
Mutation Type	DHB: diminished HLA binding or increased off-rate DR: diminished response E: escape documented in this paper RCR: replicative capacity reduced
Epitope Subtype	B
Variant Subtype	B
Method	Other
Note	KtWIILGLNK is an escape variant of KRWIILGLNK at anchor position-2 that reduces VRC less than R264K does but impairs VRC more than the R264K/S173A combination. Variant R264T does not require compensatory mutation S173A in order for the virus to survive and is typically selected without a preexisting L268X. A rare pediatric elite controller had maternal transmission of wild-type KK10 and mounted a strong response until selection of the R264T mutant which resulted in loss of KK10-response and progression to AIDS.

Variant ID.	`3717`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KqWIILGLNK`
Mutations	R/Q
Epitope Location	R2Q
HXB2 Location	R264Q
Mutation Type	E: escape documented in this paper RCR: replicative capacity reduced
Epitope Subtype	B
Variant Subtype	B
Method	Other
Note	KqWIILGLNK is an escape variant of KRWIILGLNK at anchor position-2 that reduces VRC.

Kloverpris2015a Henrik N. Kløverpris, Alasdair Leslie, and Philip Goulder. Role of HLA Adaptation in HIV Evolution. Front. Immunol., 6:665, 18 Jan 2016. PubMed ID: 26834742. Show all entries for this paper.