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Displaying record number 61205

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KkWIILGLNK   diminished HLA binding or increased off-rate; diminished response; escape documented in this paper; replicative capacity reduced
KgWIILGLNK   diminished HLA binding or increased off-rate; diminished response; escape documented in this paper; replicative capacity reduced
KtWIILGLNK   diminished HLA binding or increased off-rate; diminished response; escape documented in this paper; replicative capacity reduced
KqWIILGLNK   escape documented in this paper; replicative capacity reduced
Epitope Name KK10
Species (MHC/HLA human(B*27:05)

Variant Details

Showing all: 4 variant(s).


Variant ID.  3714
Epitope Seq.  KRWIILGLNK
Variant Seq.  KkWIILGLNK
Mutations R/K
Epitope Location R2K
HXB2 Location R264K
Mutation Type DHB: diminished HLA binding or increased off-rate
DR: diminished response
E: escape documented in this paper
RCR: replicative capacity reduced
Epitope Subtype B, C
Variant Subtype B, C
Method Other
Note KkWIILGLNK is a late escape variant of KRWIILGLNK at anchor position-2 that reduces VRC substantially and abrogates binding to HLA-B*27. Clade B R264K though associated with progression to AIDS requires compensatory mutation S173A in order for the virus to survive. This mutation invariably follows the less potent but escaping variant, L268X. In Clade C, R264K does not follow L268X and has compensatory mutation S165N. Other compensatory mutations to C clade R264K are found between Protease-217 or Pro-225, PVHAGPIAP, in the cyclophilin A-binding loop.


Variant ID.  3715
Epitope Seq.  KRWIILGLNK
Variant Seq.  KgWIILGLNK
Mutations R/G
Epitope Location R2G
HXB2 Location R264G
Mutation Type DHB: diminished HLA binding or increased off-rate
DR: diminished response
E: escape documented in this paper
RCR: replicative capacity reduced
Epitope Subtype B
Variant Subtype B
Method Other
Note KgWIILGLNK is an escape variant of KRWIILGLNK at anchor position-2 that reduces VRC less than R264K does but impairs VRC more than the R264K/S173A combination. Variant R264G does not require compensatory mutation S173A in order for the virus to survive and is typically selected without a preexisting L268X.


Variant ID.  3716
Epitope Seq.  KRWIILGLNK
Variant Seq.  KtWIILGLNK
Mutations R/T
Epitope Location R2T
HXB2 Location R264T
Mutation Type DHB: diminished HLA binding or increased off-rate
DR: diminished response
E: escape documented in this paper
RCR: replicative capacity reduced
Epitope Subtype B
Variant Subtype B
Method Other
Note KtWIILGLNK is an escape variant of KRWIILGLNK at anchor position-2 that reduces VRC less than R264K does but impairs VRC more than the R264K/S173A combination. Variant R264T does not require compensatory mutation S173A in order for the virus to survive and is typically selected without a preexisting L268X. A rare pediatric elite controller had maternal transmission of wild-type KK10 and mounted a strong response until selection of the R264T mutant which resulted in loss of KK10-response and progression to AIDS.


Variant ID.  3717
Epitope Seq.  KRWIILGLNK
Variant Seq.  KqWIILGLNK
Mutations R/Q
Epitope Location R2Q
HXB2 Location R264Q
Mutation Type E: escape documented in this paper
RCR: replicative capacity reduced
Epitope Subtype B
Variant Subtype B
Method Other
Note KqWIILGLNK is an escape variant of KRWIILGLNK at anchor position-2 that reduces VRC.

References

Kloverpris2015a Henrik N. Kløverpris, Alasdair Leslie, and Philip Goulder. Role of HLA Adaptation in HIV Evolution. Front. Immunol., 6:665, 18 Jan 2016. PubMed ID: 26834742. Show all entries for this paper.


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