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Displaying record number 61190

HXB2 Location Pol(313-321) Pol Epitope Map
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AIFQCSMTK

`AIFQsSMTr`		diminished response; escape documented in this paper; non-susceptible form
`AIFQsSMTK`		non-susceptible form

Epitope Name ACK9

Species (MHC/HLA) human(A*03:01)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`3699`
Epitope Seq.	`AIFQCSMTK`
Variant Seq.	`AIFQsSMTr`
Mutations	C/S K/R
Epitope Location	C5S K9R
HXB2 Location	C317S K321R
Mutation Type	DR: diminished response E: escape documented in this paper NSF: non-susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note	Pol ACK9 escape variant AIFQsSMTr did not cross-react to autologous ACK9 (AIFQCSMTK)-specific T cells during acute infection in A*0301 patients.

Variant ID.	`3700`
Epitope Seq.	`AIFQCSMTK`
Variant Seq.	`AIFQsSMTK`
Mutations	C/S
Epitope Location	C5S
HXB2 Location	C317S
Mutation Type	NSF: non-susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note	Pol ACK9 non-escape variant AIFQsSMTK did not cross-react to autologous ACK9 (AIFQCSMTK)-specific T cells during acute and chronic infection in A*0301 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.