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Found 1 matching record:

Displaying record number 61190

HXB2 Location  Pol(313-321)   Pol Epitope Map
View variants at this location
Epitope AIFQCSMTK   Epitope Alignment
Variants
AIFQsSMTr   diminished response; escape documented in this paper; non-susceptible form
AIFQsSMTK   non-susceptible form
Epitope Name ACK9
Species (MHC/HLA human(A*03:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3699
Epitope Seq.  AIFQCSMTK
Variant Seq.  AIFQsSMTr
Mutations C/S K/R
Epitope Location C5S K9R
HXB2 Location C317S K321R
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol ACK9 escape variant AIFQsSMTr did not cross-react to autologous ACK9 (AIFQCSMTK)-specific T cells during acute infection in A*0301 patients.


Variant ID.  3700
Epitope Seq.  AIFQCSMTK
Variant Seq.  AIFQsSMTK
Mutations C/S
Epitope Location C5S
HXB2 Location C317S
Mutation Type NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol ACK9 non-escape variant AIFQsSMTK did not cross-react to autologous ACK9 (AIFQCSMTK)-specific T cells during acute and chronic infection in A*0301 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


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