Found 1 matching record:
HXB2 Location | Gag(84-91) | Gag Epitope Map
View variants at this location |
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Epitope |
TMYCVHQK
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Epitope Alignment | ||||||||||
Variants |
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Epitope Name | TMK11 | |||||||||||
Species (MHC/HLA) | human(A*11:01) |
Showing all: 3 variant(s).
Variant ID. | 3680 |
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Epitope Seq. | TMYCVHQK |
Variant Seq. | TlYCVHQr |
Mutations | M/L K/R |
Epitope Location | M2L K8R |
HXB2 Location | M85L K91R |
Mutation Type | DR: diminished response E: escape documented in this paper NSF: non-susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other |
Note | Gag TMK11 escape variant TlYCVHQr did not cross-react to autologous TMK11 (TMYCVHQK)-specific T cells during acute and chronic infection in A*1101 patients. |
Variant ID. | 3681 |
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Epitope Seq. | TMYCVHQK |
Variant Seq. | vlYCVHQr |
Mutations | T/V M/L K/R |
Epitope Location | T1V M2L K8R |
HXB2 Location | T84V M85L K91R |
Mutation Type | DR: diminished response E: escape documented in this paper NSF: non-susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other |
Note | Gag TMK11 escape variant vlYCVHQr did not cross-react to autologous TMK11 (TMYCVHQK)-specific T cells during acute and chronic infection in A*1101 patients. |
Variant ID. | 3682 |
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Epitope Seq. | TMYCVHQK |
Variant Seq. | TlYCVHQK |
Mutations | M/L |
Epitope Location | M2L |
HXB2 Location | M85L |
Mutation Type | DR: diminished response E: escape documented in this paper NSF: non-susceptible form SF: susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other |
Note | Gag TMK11 escape variant TlYCVHQK did not cross-react to autologous TMK11 (TMYCVHQK)-specific T cells during acute infection but did cross-react during chronic infection in A*1101 patients. |
Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.
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