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Displaying record number 61169

HXB2 Location  Pol(283-290)   Pol Epitope Map
View variants at this location
Epitope TAFTIPSI   Epitope Alignment
Variants
TAFTIPSt   diminished response; escape documented in this paper; non-susceptible form
TAFTIPSv   diminished response; escape documented in this paper; non-susceptible form
Epitope Name TI8
Species (MHC/HLA human(B*51:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3641
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSt
Mutations I/T
Epitope Location I8T
HXB2 Location I290T
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol TI8 escape variant TAFTIPSt did not cross-react to autologous TI8 (TAFTIPSI)-specific T cells during acute and chronic infection in B*1501 patients.


Variant ID.  3642
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSv
Mutations I/V
Epitope Location I8V
HXB2 Location I290V
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol TI8 escape variant TAFTIPSv did not cross-react to autologous TI8 (TAFTIPSI)-specific T cells during acute and chronic infection in B*1501 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


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