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Displaying record number 61169

HXB2 Location Pol(283-290) Pol Epitope Map
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TAFTIPSI

`TAFTIPSt`		diminished response; escape documented in this paper; non-susceptible form
`TAFTIPSv`		diminished response; escape documented in this paper; non-susceptible form

Epitope Name TI8

Species (MHC/HLA) human(B*51:01)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`3641`
Epitope Seq.	`TAFTIPSI`
Variant Seq.	`TAFTIPSt`
Mutations	I/T
Epitope Location	I8T
HXB2 Location	I290T
Mutation Type	DR: diminished response E: escape documented in this paper NSF: non-susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note	Pol TI8 escape variant TAFTIPSt did not cross-react to autologous TI8 (TAFTIPSI)-specific T cells during acute and chronic infection in B*1501 patients.

Variant ID.	`3642`
Epitope Seq.	`TAFTIPSI`
Variant Seq.	`TAFTIPSv`
Mutations	I/V
Epitope Location	I8V
HXB2 Location	I290V
Mutation Type	DR: diminished response E: escape documented in this paper NSF: non-susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note	Pol TI8 escape variant TAFTIPSv did not cross-react to autologous TI8 (TAFTIPSI)-specific T cells during acute and chronic infection in B*1501 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.