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Displaying record number 61168

HXB2 Location  Pol(464-473)   Pol Epitope Map
View variants at this location
Epitope ILKEPVHGVY   Epitope Alignment
Variants
ILKEPVHGaY   diminished response; escape documented in this paper; non-susceptible form
ILKEtVHGaY   diminished response; escape documented in this paper; non-susceptible form
ILKEsVHGaY   diminished response; escape documented in this paper; non-susceptible form
ILKaPVHGaY   diminished response; escape documented in this paper; non-susceptible form
ILKkPVHGaY   diminished response; escape documented in this paper; non-susceptible form
ILrEPVHGaY   diminished response; escape documented in this paper; non-susceptible form
ILrEPVHGVY   diminished response; escape documented in this paper; non-susceptible form
Epitope Name IY10
Species (MHC/HLA human(B*15:10)

Variant Details

Showing all: 7 variant(s).


Variant ID.  3634
Epitope Seq.  ILKEPVHGVY
Variant Seq.  ILKEPVHGaY
Mutations V/A
Epitope Location V9A
HXB2 Location V472A
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol IY10 escape variant ILKEPVHGaY did not cross-react to autologous IY10 (ILKEPVHGVY)-specific T cells during acute infection in B*1510 patients.


Variant ID.  3635
Epitope Seq.  ILKEPVHGVY
Variant Seq.  ILKEtVHGaY
Mutations P/T V/A
Epitope Location P5T V9A
HXB2 Location P468T V472A
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol IY10 escape variant ILKEtVHGaY did not cross-react to autologous IY10 (ILKEPVHGVY)-specific T cells during acute infection in B*1510 patients.


Variant ID.  3636
Epitope Seq.  ILKEPVHGVY
Variant Seq.  ILKEsVHGaY
Mutations P/S V/A
Epitope Location P5S V9A
HXB2 Location P468S V472A
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol IY10 escape variant ILKEsVHGaY did not cross-react to autologous IY10 (ILKEPVHGVY)-specific T cells during acute infection in B*1510 patients.


Variant ID.  3637
Epitope Seq.  ILKEPVHGVY
Variant Seq.  ILKaPVHGaY
Mutations E/A V/A
Epitope Location E4A V9A
HXB2 Location E467A V472A
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol IY10 escape variant ILKaPVHGaY did not cross-react to autologous IY10 (ILKEPVHGVY)-specific T cells during acute infection in B*1510 patients.


Variant ID.  3638
Epitope Seq.  ILKEPVHGVY
Variant Seq.  ILKkPVHGaY
Mutations E/K V/A
Epitope Location E4K V9A
HXB2 Location E467K V472A
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol IY10 escape variant ILKkPVHGaY did not cross-react to autologous IY10 (ILKEPVHGVY)-specific T cells during acute infection in B*1510 patients.


Variant ID.  3639
Epitope Seq.  ILKEPVHGVY
Variant Seq.  ILrEPVHGaY
Mutations E/K V/A
Epitope Location E4K V9A
HXB2 Location E467K V472A
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol IY10 escape variant ILrEPVHGaY did not cross-react to autologous IY10 (ILKEPVHGVY)-specific T cells during acute infection in B*1510 patients.


Variant ID.  3640
Epitope Seq.  ILKEPVHGVY
Variant Seq.  ILrEPVHGVY
Mutations K/R
Epitope Location K3R
HXB2 Location K466R
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol IY10 escape variant ILrEPVHGVY did not cross-react to autologous IY10 (ILKEPVHGVY)-specific T cells during acute and chronic infection in B*1510 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


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