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Displaying record number 61160

HXB2 Location  Nef(128-137)   Nef Epitope Map
View variants at this location
Epitope TPGPGIRYPL   Epitope Alignment
Variants
TPGPGvRYPL   diminished response; escape documented in this paper; susceptible form
TPGPGvRfPL   diminished response; escape documented in this paper; susceptible form
TPGPGvRwPL   diminished response; escape documented in this paper; susceptible form
TPGPGvRlPL   diminished response; escape documented in this paper; susceptible form
TPGPGtRfPL   diminished response; escape documented in this paper; susceptible form
Epitope Name TL10
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 5 variant(s).


Variant ID.  3601
Epitope Seq.  TPGPGIRYPL
Variant Seq.  TPGPGvRYPL
Mutations I/V
Epitope Location I6V
HXB2 Location I133V
Mutation Type DR: diminished response
E: escape documented in this paper
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef TL10 escape variant TPGPGvRYPL cross-reacted to autologous TL10(TPGPGIRYPL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3602
Epitope Seq.  TPGPGIRYPL
Variant Seq.  TPGPGvRfPL
Mutations I/V Y/F
Epitope Location I6V Y8F
HXB2 Location I133V Y135F
Mutation Type DR: diminished response
E: escape documented in this paper
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef TL10 escape variant TPGPGvRfPL cross-reacted to autologous TL10(TPGPGIRYPL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3603
Epitope Seq.  TPGPGIRYPL
Variant Seq.  TPGPGvRwPL
Mutations I/V Y/W
Epitope Location I6V Y8W
HXB2 Location I133V Y135W
Mutation Type DR: diminished response
E: escape documented in this paper
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef TL10 escape variant TPGPGvRwPL cross-reacted to autologous TL10(TPGPGIRYPL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3604
Epitope Seq.  TPGPGIRYPL
Variant Seq.  TPGPGvRlPL
Mutations I/V Y/L
Epitope Location I6V Y8L
HXB2 Location I133V Y135L
Mutation Type DR: diminished response
E: escape documented in this paper
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef TL10 escape variant TPGPGvRlPL did not cross-react to autologous TL10(TPGPGIRYPL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3605
Epitope Seq.  TPGPGIRYPL
Variant Seq.  TPGPGtRfPL
Mutations I/T Y/F
Epitope Location I6T Y8F
HXB2 Location I133T Y135F
Mutation Type DR: diminished response
E: escape documented in this paper
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef TL10 escape variant TPGPGtRfPL did not cross-react to autologous TL10(TPGPGIRYPL)-specific T cells during acute infection in B*0702 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


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