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Found 1 matching record:

Displaying record number 61132

HXB2 Location  Nef(77-85)   Nef Epitope Map
View variants at this location
Epitope RPMTYKGAL   Epitope Alignment
Variants
RPMTfKGAL   inferred escape; literature escape
Epitope Name RL9
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3572
Epitope Seq.  RPMTYKGAL
Variant Seq.  RPMTfKGAL
Mutations Y/F
Epitope Location Y5F
HXB2 Location Y81F
Mutation Type IE: inferred escape
LE: literature escape
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, HLA binding, Intracellular cytokine staining, Other
Note RFL9, RPMTfKGAL, variant of RL9 is the adapted form that decreases HLA-B*0702-associated CTL immune response to viral infection.

References

Carlson2016 Jonathan M. Carlson, Victor Y. Du, Nico Pfeifer, Anju Bansal, Vincent Y. F. Tan, Karen Power, Chanson J. Brumme, Anat Kreimer, Charles E. DeZiel, Nicolo Fusi, Malinda Schaefer, Mark A. Brockman, Jill Gilmour, Matt A. Price, William Kilembe, Richard Haubrich, Mina John, Simon Mallal, Roger Shapiro, John Frater, P. Richard Harrigan, Thumbi Ndung'u, Susan Allen, David Heckerman, John Sidney, Todd M. Allen, Philip J. R. Goulder, Zabrina L. Brumme, Eric Hunter, and Paul A. Goepfert. Impact of Pre-Adapted HIV Transmission. Nat. Med., 22(6):606-613, Jun 2016. PubMed ID: 27183217. Show all entries for this paper.


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