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Displaying record number 61132

HXB2 Location Nef(77-85) Nef Epitope Map
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Epitope

RPMTYKGAL

Epitope Alignment

Variants

RPMTfKGAL inferred escape; literature escape

Epitope Name RL9

Species (MHC/HLA) human(B*07:02)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3572`
Epitope Seq.	`RPMTYKGAL`
Variant Seq.	`RPMTfKGAL`
Mutations	Y/F
Epitope Location	Y5F
HXB2 Location	Y81F
Mutation Type	IE: inferred escape LE: literature escape
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, HLA binding, Intracellular cytokine staining, Other
Note	RFL9, RPMTfKGAL, variant of RL9 is the adapted form that decreases HLA-B*0702-associated CTL immune response to viral infection.

References

Carlson2016 Jonathan M. Carlson, Victor Y. Du, Nico Pfeifer, Anju Bansal, Vincent Y. F. Tan, Karen Power, Chanson J. Brumme, Anat Kreimer, Charles E. DeZiel, Nicolo Fusi, Malinda Schaefer, Mark A. Brockman, Jill Gilmour, Matt A. Price, William Kilembe, Richard Haubrich, Mina John, Simon Mallal, Roger Shapiro, John Frater, P. Richard Harrigan, Thumbi Ndung'u, Susan Allen, David Heckerman, John Sidney, Todd M. Allen, Philip J. R. Goulder, Zabrina L. Brumme, Eric Hunter, and Paul A. Goepfert. Impact of Pre-Adapted HIV Transmission. Nat. Med., 22(6):606-613, Jun 2016. PubMed ID: 27183217. Show all entries for this paper.