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Found 1 matching record:

Displaying record number 59436

HXB2 Location  Pol(743-751)   Pol Epitope Map
View variants at this location
Epitope LPPIVAKEI   Epitope Alignment
Variants
LPPvVAKEI   escape documented in this paper; observed variant
LPPIVArEI   escape documented in this paper; observed variant
Epitope Name Int-LI9
Species (MHC/HLA human(B*42:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3491
Epitope Seq.  LPPIVAKEI
Variant Seq.  LPPvVAKEI
Mutations I/V
Epitope Location I4V
HXB2 Location I31V
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 51% of B*4201+ and 17% of B*4201- subjects (n=1857) carried this escape variant, LPPvVAKEI.


Variant ID.  3492
Epitope Seq.  LPPIVAKEI
Variant Seq.  LPPIVArEI
Mutations K/R
Epitope Location K7R
HXB2 Location K34R
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 28% of B*4201+ and 2% of B*4201- subjects (n=1857) carried this escape variant, LPPIVArEI.

References

Kloverpris2015 Henrik N Kløverpris, Reuben McGregor, James E. McLaren, Kristin Ladell, Mikkel Harndahl, Anette Stryhn, Jonathan M. Carlson, Catherine Koofhethile, Bram Gerritsen, Can Keşmir, Fabian Chen, Lynn Riddell, Graz Luzzi, Alasdair Leslie, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, David A. Price, and Philip J. Goulder. CD8+ TCR Bias and Immunodominance in HIV-1 Infection. J. Immunol., 194(11):5329-5345, 1 Jun 2015. PubMed ID: 25911754. Show all entries for this paper.


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