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Found 1 matching record:

Displaying record number 59424

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KaWIILGLNK   diminished HLA binding or increased off-rate
KRWIIaGLNK   diminished HLA binding or increased off-rate
KaWIIaGLNK   diminished HLA binding or increased off-rate
Epitope Name KK10
Species (MHC/HLA human(B*27:05)

Variant Details

Showing all: 3 variant(s).


Variant ID.  3474
Epitope Seq.  KRWIILGLNK
Variant Seq.  KaWIILGLNK
Mutations R/A
Epitope Location R2A
HXB2 Location R264A
Mutation Type DHB: diminished HLA binding or increased off-rate
Method Chromium-release assay
Note Variant R2A, KaWIILGLNK, showed reduced TCR recognition in an in vitro chromium release assay.


Variant ID.  3475
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIIaGLNK
Mutations L/A
Epitope Location L6A
HXB2 Location L268A
Mutation Type DHB: diminished HLA binding or increased off-rate
Method Chromium-release assay
Note Variants L6A, KRWIIaGLNK, showed reduced TCR recognition in an in vitro chromium release assay.


Variant ID.  3476
Epitope Seq.  KRWIILGLNK
Variant Seq.  KaWIIaGLNK
Mutations R/A L/A
Epitope Location R2A L6A
HXB2 Location R264A L268A
Mutation Type DHB: diminished HLA binding or increased off-rate
Method Chromium-release assay
Note Variant KaWIIaGLNK, the dual mutant R2AL6A, showed reduced TCR recognition in an in vitro chromium release assay.

References

Xia2014 Zhen Xia, Huabiao Chen, Seung-gu Kang, Tien Huynh, Justin W. Fang, Pedro A. Lamothe, Bruce D. Walker, and Ruhong Zhou. The Complex and Specific pMHC Interactions with Diverse HIV-1 TCR Clonotypes Reveal a Structural Basis for Alterations in CTL Function. Sci. Rep., 4:4087, 2014. PubMed ID: 24522437. Show all entries for this paper.


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