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Displaying record number 59424

HXB2 Location Gag(263-272) Gag Epitope Map
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KRWIILGLNK

`KaWIILGLNK`		diminished HLA binding or increased off-rate
`KRWIIaGLNK`		diminished HLA binding or increased off-rate
`KaWIIaGLNK`		diminished HLA binding or increased off-rate

Epitope Name KK10

Species (MHC/HLA) human(B*27:05)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`3474`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KaWIILGLNK`
Mutations	R/A
Epitope Location	R2A
HXB2 Location	R264A
Mutation Type	DHB: diminished HLA binding or increased off-rate
Method	Chromium-release assay
Note	Variant R2A, KaWIILGLNK, showed reduced TCR recognition in an in vitro chromium release assay.

Variant ID.	`3475`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KRWIIaGLNK`
Mutations	L/A
Epitope Location	L6A
HXB2 Location	L268A
Mutation Type	DHB: diminished HLA binding or increased off-rate
Method	Chromium-release assay
Note	Variants L6A, KRWIIaGLNK, showed reduced TCR recognition in an in vitro chromium release assay.

Variant ID.	`3476`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KaWIIaGLNK`
Mutations	R/A L/A
Epitope Location	R2A L6A
HXB2 Location	R264A L268A
Mutation Type	DHB: diminished HLA binding or increased off-rate
Method	Chromium-release assay
Note	Variant KaWIIaGLNK, the dual mutant R2AL6A, showed reduced TCR recognition in an in vitro chromium release assay.

References

Xia2014 Zhen Xia, Huabiao Chen, Seung-gu Kang, Tien Huynh, Justin W. Fang, Pedro A. Lamothe, Bruce D. Walker, and Ruhong Zhou. The Complex and Specific pMHC Interactions with Diverse HIV-1 TCR Clonotypes Reveal a Structural Basis for Alterations in CTL Function. Sci. Rep., 4:4087, 2014. PubMed ID: 24522437. Show all entries for this paper.