HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 1 matching record:

Displaying record number 59387

HXB2 Location  Rev(12-20)   Rev Epitope Map
View variants at this location
Epitope LLQAVRIIK   Epitope Alignment
Variants
LLQAVkIIK   diminished response; escape documented in this paper
LLQAVRIIr   diminished response; escape documented in this paper
Species (MHC/HLA human

Variant Details

Showing all: 2 variant(s).


Variant ID.  3468
Epitope Seq.  LLQAVRIIK
Variant Seq.  LLQAVkIIK
Mutations R/K
Epitope Location R6K
HXB2 Location R17K
Mutation Type DR: diminished response
E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Variant LLQAVkIIK was present in the patient's sequences and had greatly diminished response compared to wt epitope.


Variant ID.  3469
Epitope Seq.  LLQAVRIIK
Variant Seq.  LLQAVRIIr
Mutations K/R
Epitope Location K9R
HXB2 Location K20R
Mutation Type DR: diminished response
E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Variant was present in the patient's sequences and had diminished response compared to wt epitope.

References

Ritchie2014 Adam John Ritchie, Fangping Cai, Nicola M. G. Smith, Sheri Chen, Hongshuo Song, Simon Brackenridge, Salim S. Abdool Karim, Bette T. Korber, Andrew J. McMichael, Feng Gao, and Nilu Goonetilleke. Recombination-Mediated Escape from Primary CD8+ T Cells in Acute HIV-1 Infection. Retrovirology, 11:69, 2014. PubMed ID: 25212771. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health