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Found 1 matching record:

Displaying record number 59292

HXB2 Location  gp160(352-361)   gp160 Epitope Map
View variants at this location
Epitope QFRNKTIVF   Epitope Alignment
Variants
QFkNKTIVF   reversion
QFsNKTIVF   observed variant
QFRNKaIVF   observed variant
QFnNKTIVF   observed variant
QFkdKTIVF   observed variant
QFkNKaIVF   observed variant
Species (MHC/HLA human(B*57)

Variant Details

Showing all: 6 variant(s).


Variant ID.  3455
Epitope Seq.  QFRNKTIVF
Variant Seq.  QFkNKTIVF
Mutations R/K
Epitope Location R3K
HXB2 Location R354K
Mutation Type R: reversion
Epitope Subtype B
Variant Subtype B
Method Relative replication capacity assay, Sequence
Note Reversion mutation QFkNKTIVF was predominant in the patient's sequences at all timepoints from 14 to 592 days post-seroconversion, at 73% on d14, 100% on d32, 80% on d102, 83% on d159, and 60% on d592. The mutant had the same fitness compared to the wild type sequence.


Variant ID.  4187
Epitope Seq.  QFRNKTIVF
Variant Seq.  QFsNKTIVF
Mutations R/S
Epitope Location R3S
HXB2 Location R354S
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note Observed variant QFsNKTIVF was seen in Patient CH077's sequences post-seroconversion at 7% on d14.


Variant ID.  4188
Epitope Seq.  QFRNKTIVF
Variant Seq.  QFRNKaIVF
Mutations T/A
Epitope Location T6A
HXB2 Location T357A
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note Observed variant QFRNKaIVF was seen in Patient CH077's sequences post-seroconversion at 7% on d14.


Variant ID.  4189
Epitope Seq.  QFRNKTIVF
Variant Seq.  QFnNKTIVF
Mutations R/N
Epitope Location R3N
HXB2 Location R354N
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note Observed variant QFnNKTIVF was seen in Patient CH077's sequences post-seroconversion at 20%% on d102, and 17% on d159.


Variant ID.  4190
Epitope Seq.  QFRNKTIVF
Variant Seq.  QFkdKTIVF
Mutations R/K N/D
Epitope Location R3K N4D
HXB2 Location R354K N355D
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note Observed variant QFkdKTIVF was seen in Patient CH077's sequences post-seroconversion at 20% on d592.


Variant ID.  4191
Epitope Seq.  QFRNKTIVF
Variant Seq.  QFkNKaIVF
Mutations R/K T/A
Epitope Location R3K T6A
HXB2 Location R354K T357A
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note Observed variant QFkNKaIVF was seen in Patient CH077's sequences post-seroconversion at 20% on d592.

References

Song2014 Hongshuo Song, Bhavna Hora, Tanmoy Bhattacharya, Nilu Goonetilleke, Michael K. P. Liu, Kevin Wiehe, Hui Li, Shilpa S. Iyer, Andrew J. McMichael, Alan S. Perelson, and Feng Gao. Reversion and T Cell Escape Mutations Compensate the Fitness Loss of a CD8+ T Cell Escape Mutant in Their Cognate Transmitted/Founder Virus. PLoS One, 9(7):e102734, 2014. PubMed ID: 25028937. Show all entries for this paper.


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