Found 1 matching record:
HXB2 Location | Nef(136-145) | Nef Epitope Map
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Epitope |
PLTFGWCFKL
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Epitope Alignment | ||||||||||||||||||||||
Variants |
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Species (MHC/HLA) | human |
Showing all: 7 variant(s).
Variant ID. | 3432 |
---|---|
Epitope Seq. | PLTFGWCFKL |
Variant Seq. | PLTLGWCFKL |
Mutations | F/L |
Epitope Location | F4L |
HXB2 Location | F139L |
Mutation Type | OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | First variant detected; seen only at early post-seroconversion period; no Elispot response. |
Variant ID. | 3433 |
---|---|
Epitope Seq. | PLTFGWCFKL |
Variant Seq. | PITFGWCFKL |
Mutations | L/I |
Epitope Location | L2I |
HXB2 Location | L137I |
Mutation Type | SF: susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | Second variant detected; seen only at early post-seroconversion period; strongly positive Elispot response ˜200 SFC/106PBMC . |
Variant ID. | 3434 |
---|---|
Epitope Seq. | PLTFGWCFKL |
Variant Seq. | PVTFGWCFKL |
Mutations | L/V |
Epitope Location | L2V |
HXB2 Location | L137V |
Mutation Type | SF: susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | Third variant detected; seen in early post-seroconversion period; positive Elispot response ˜200 SFC/106PBMC . |
Variant ID. | 3435 |
---|---|
Epitope Seq. | PLTFGWCFKL |
Variant Seq. | PLCFGWCFKL |
Mutations | T/C |
Epitope Location | T3C |
HXB2 Location | T138C |
Mutation Type | SF: susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | Fourth variant detected; seen in the late post-seroconversion, early ART, and late ART periods; positive Elispot response in the late post-seroconversion (<50 SFC/106PBMC ) and early ART (˜50 SFC/106PBMC ) periods; response lost in the late ART period. |
Variant ID. | 3436 |
---|---|
Epitope Seq. | PLTFGWCFKL |
Variant Seq. | PVCFGWCFKL |
Mutations | L/V T/C |
Epitope Location | L2V T3C |
HXB2 Location | L137V T138C |
Mutation Type | OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | Fifth variant detected; seen in the late post-seroconversion period; no Elispot response. |
Variant ID. | 3437 |
---|---|
Epitope Seq. | PLTFGWCFKL |
Variant Seq. | PMCFGWCFKL |
Mutations | L/M T/C |
Epitope Location | L2M T3C |
HXB2 Location | L137M T138C |
Mutation Type | SF: susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | Sixth variant detected; seen in the late post-seroconversion, early ART and late ART periods; positive Elispot response only in the early ART period (˜100 SFC/106PBMC ). |
Variant ID. | 3438 |
---|---|
Epitope Seq. | PLTFGWCFKL |
Variant Seq. | PLCFGWCFKP |
Mutations | L/P T/C |
Epitope Location | L10P T3C |
HXB2 Location | L145P T138C |
Mutation Type | SF: susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | Seventh variant detected; seen in the late post-seroconversion period; Elispot response <50 SFC/106PBMC . |
Melhem2014 Nada M Melhem, Kellie N. Smith, Xiao-Li Huang, Bonnie A Colleton, Weimin Jiang, Robbie B. Mailliard, James I. Mullins, and Charles R. Rinaldo. The Impact of Viral Evolution and Frequency of Variant Epitopes on Primary and Memory Human Immunodeficiency Virus Type 1-Specific CD8+ T Cell Responses. Virology, 450-451:34-48, Feb 2014. PubMed ID: 24503065. Show all entries for this paper.
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