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HIV Molecular Immunology Database

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Found 1 matching record:

Displaying record number 59262

HXB2 Location  Nef(136-145)   Nef Epitope Map
View variants at this location
Epitope PLTFGWCFKL   Epitope Alignment
Variants
PLTLGWCFKL   observed variant
PITFGWCFKL   susceptible form
PVTFGWCFKL   susceptible form
PLCFGWCFKL   susceptible form
PVCFGWCFKL   observed variant
PMCFGWCFKL   susceptible form
PLCFGWCFKP   susceptible form
Species (MHC/HLA human

Variant Details

Showing all: 7 variant(s).


Variant ID.  3432
Epitope Seq.  PLTFGWCFKL
Variant Seq.  PLTLGWCFKL
Mutations F/L
Epitope Location F4L
HXB2 Location F139L
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note First variant detected; seen only at early post-seroconversion period; no Elispot response.


Variant ID.  3433
Epitope Seq.  PLTFGWCFKL
Variant Seq.  PITFGWCFKL
Mutations L/I
Epitope Location L2I
HXB2 Location L137I
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Second variant detected; seen only at early post-seroconversion period; strongly positive Elispot response ˜200 SFC/106PBMC .


Variant ID.  3434
Epitope Seq.  PLTFGWCFKL
Variant Seq.  PVTFGWCFKL
Mutations L/V
Epitope Location L2V
HXB2 Location L137V
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Third variant detected; seen in early post-seroconversion period; positive Elispot response ˜200 SFC/106PBMC .


Variant ID.  3435
Epitope Seq.  PLTFGWCFKL
Variant Seq.  PLCFGWCFKL
Mutations T/C
Epitope Location T3C
HXB2 Location T138C
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Fourth variant detected; seen in the late post-seroconversion, early ART, and late ART periods; positive Elispot response in the late post-seroconversion (<50 SFC/106PBMC ) and early ART (˜50 SFC/106PBMC ) periods; response lost in the late ART period.


Variant ID.  3436
Epitope Seq.  PLTFGWCFKL
Variant Seq.  PVCFGWCFKL
Mutations L/V T/C
Epitope Location L2V T3C
HXB2 Location L137V T138C
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Fifth variant detected; seen in the late post-seroconversion period; no Elispot response.


Variant ID.  3437
Epitope Seq.  PLTFGWCFKL
Variant Seq.  PMCFGWCFKL
Mutations L/M T/C
Epitope Location L2M T3C
HXB2 Location L137M T138C
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Sixth variant detected; seen in the late post-seroconversion, early ART and late ART periods; positive Elispot response only in the early ART period (˜100 SFC/106PBMC ).


Variant ID.  3438
Epitope Seq.  PLTFGWCFKL
Variant Seq.  PLCFGWCFKP
Mutations L/P T/C
Epitope Location L10P T3C
HXB2 Location L145P T138C
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Seventh variant detected; seen in the late post-seroconversion period; Elispot response <50 SFC/106PBMC .

References

Melhem2014 Nada M Melhem, Kellie N. Smith, Xiao-Li Huang, Bonnie A Colleton, Weimin Jiang, Robbie B. Mailliard, James I. Mullins, and Charles R. Rinaldo. The Impact of Viral Evolution and Frequency of Variant Epitopes on Primary and Memory Human Immunodeficiency Virus Type 1-Specific CD8+ T Cell Responses. Virology, 450-451:34-48, Feb 2014. PubMed ID: 24503065. Show all entries for this paper.


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