HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Nef(77-85) | Nef Epitope Map
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| Epitope |
RPMTWKGAL
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Epitope Alignment | |||||||||||||||||||
| Variants |
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| Species (MHC/HLA) | human | ||||||||||||||||||||
Showing all: 6 variant(s).
| Variant ID. | 3411 |
|---|---|
| Epitope Seq. | RPMTWKGAL |
| Variant Seq. | RPMTWKAAL |
| Mutations | G/A |
| Epitope Location | G7A |
| HXB2 Location | G83A |
| Mutation Type | SF: susceptible form |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy, Sequence |
| Note | First variant detected; seen throughout infection; Elispot responses in early post-seroconversion (˜100 SFC/106PBMC ), last post-SC (seroconversion) (at ˜50 SFC/106PBMC ), and early ART (˜100 SFC) periods. |
| Variant ID. | 3412 |
|---|---|
| Epitope Seq. | RPMTWKGAL |
| Variant Seq. | RPMTYKGAL |
| Mutations | W/Y |
| Epitope Location | W5Y |
| HXB2 Location | W81Y |
| Mutation Type | SF: susceptible form |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy, Sequence |
| Note | Second variant detected; seen only in early post-seroconversion; positive Elispot response ˜50 SFC/106PBMC . |
| Variant ID. | 3413 |
|---|---|
| Epitope Seq. | RPMTWKGAL |
| Variant Seq. | RPMTRKAAL |
| Mutations | W/R G/A |
| Epitope Location | W5R G7A |
| HXB2 Location | W81R G83A |
| Mutation Type | SF: susceptible form |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy, Sequence |
| Note | Third variant detected; seen only in early post-seroconversion; positive Elispot response ˜200 SFC/106PBMC . |
| Variant ID. | 3414 |
|---|---|
| Epitope Seq. | RPMTWKGAL |
| Variant Seq. | RPMTCKGAL |
| Mutations | W/C |
| Epitope Location | W5C |
| HXB2 Location | W81C |
| Mutation Type | SF: susceptible form |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy, Sequence |
| Note | Fourth variant detected; seen only in early post-seroconversion; positive Elispot response ˜100 SFC/106PBMC . |
| Variant ID. | 3415 |
|---|---|
| Epitope Seq. | RPMTWKGAL |
| Variant Seq. | RPMTYKAAL |
| Mutations | W/Y G/A |
| Epitope Location | W5Y G7A |
| HXB2 Location | W81Y G83A |
| Mutation Type | OV: observed variant |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy, Sequence |
| Note | Fifth variant detected; seen only in late post-seroconversion; no Elispot response. |
| Variant ID. | 3416 |
|---|---|
| Epitope Seq. | RPMTWKGAL |
| Variant Seq. | RPITYKAAL |
| Mutations | M/I W/Y G/A |
| Epitope Location | M3I W5Y G7A |
| HXB2 Location | M79I W81Y G83A |
| Mutation Type | SF: susceptible form |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy, Sequence |
| Note | Sixth variant detected; seen in early and late ART periods; Elispot response ˜200 SFC/106PBMC in early ART period and ˜150 SFC/106PBMC in late ART period. |
Melhem2014 Nada M Melhem, Kellie N. Smith, Xiao-Li Huang, Bonnie A Colleton, Weimin Jiang, Robbie B. Mailliard, James I. Mullins, and Charles R. Rinaldo. The Impact of Viral Evolution and Frequency of Variant Epitopes on Primary and Memory Human Immunodeficiency Virus Type 1-Specific CD8+ T Cell Responses. Virology, 450-451:34-48, Feb 2014. PubMed ID: 24503065. Show all entries for this paper.