HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 1 matching record:

Displaying record number 59250

HXB2 Location  Nef(77-85)   Nef Epitope Map
View variants at this location
Epitope RPMTWKGAL   Epitope Alignment
Variants
RPMTWKAAL   susceptible form
RPMTYKGAL   susceptible form
RPMTRKAAL   susceptible form
RPMTCKGAL   susceptible form
RPMTYKAAL   observed variant
RPITYKAAL   susceptible form
Species (MHC/HLA human

Variant Details

Showing all: 6 variant(s).


Variant ID.  3411
Epitope Seq.  RPMTWKGAL
Variant Seq.  RPMTWKAAL
Mutations G/A
Epitope Location G7A
HXB2 Location G83A
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note First variant detected; seen throughout infection; Elispot responses in early post-seroconversion (˜100 SFC/106PBMC ), last post-SC (seroconversion) (at ˜50 SFC/106PBMC ), and early ART (˜100 SFC) periods.


Variant ID.  3412
Epitope Seq.  RPMTWKGAL
Variant Seq.  RPMTYKGAL
Mutations W/Y
Epitope Location W5Y
HXB2 Location W81Y
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Second variant detected; seen only in early post-seroconversion; positive Elispot response ˜50 SFC/106PBMC .


Variant ID.  3413
Epitope Seq.  RPMTWKGAL
Variant Seq.  RPMTRKAAL
Mutations W/R G/A
Epitope Location W5R G7A
HXB2 Location W81R G83A
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Third variant detected; seen only in early post-seroconversion; positive Elispot response ˜200 SFC/106PBMC .


Variant ID.  3414
Epitope Seq.  RPMTWKGAL
Variant Seq.  RPMTCKGAL
Mutations W/C
Epitope Location W5C
HXB2 Location W81C
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Fourth variant detected; seen only in early post-seroconversion; positive Elispot response ˜100 SFC/106PBMC .


Variant ID.  3415
Epitope Seq.  RPMTWKGAL
Variant Seq.  RPMTYKAAL
Mutations W/Y G/A
Epitope Location W5Y G7A
HXB2 Location W81Y G83A
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Fifth variant detected; seen only in late post-seroconversion; no Elispot response.


Variant ID.  3416
Epitope Seq.  RPMTWKGAL
Variant Seq.  RPITYKAAL
Mutations M/I W/Y G/A
Epitope Location M3I W5Y G7A
HXB2 Location M79I W81Y G83A
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Sixth variant detected; seen in early and late ART periods; Elispot response ˜200 SFC/106PBMC in early ART period and ˜150 SFC/106PBMC in late ART period.

References

Melhem2014 Nada M Melhem, Kellie N. Smith, Xiao-Li Huang, Bonnie A Colleton, Weimin Jiang, Robbie B. Mailliard, James I. Mullins, and Charles R. Rinaldo. The Impact of Viral Evolution and Frequency of Variant Epitopes on Primary and Memory Human Immunodeficiency Virus Type 1-Specific CD8+ T Cell Responses. Virology, 450-451:34-48, Feb 2014. PubMed ID: 24503065. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health