Found 1 matching record:
HXB2 Location | Gag(77-85) | Gag Epitope Map
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Epitope |
SLFNTVATL
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Epitope Alignment | ||||||||||||||||
Variants |
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Species (MHC/HLA) | human(A*02:01) |
Showing all: 5 variant(s).
Variant ID. | 3368 |
---|---|
Epitope Seq. | SLFNTVATL |
Variant Seq. | SLFNTVAAL |
Mutations | T/A |
Epitope Location | T8A |
HXB2 Location | T84A |
Mutation Type | DR: diminished response |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | First variant to arise; seen only in early post-seroconversion period; Elispot response <100 SFC/106PBMC. |
Variant ID. | 3369 |
---|---|
Epitope Seq. | SLFNTVATL |
Variant Seq. | SLFNTVATP |
Mutations | L/P |
Epitope Location | L9P |
HXB2 Location | L85P |
Mutation Type | DR: diminished response |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | Second variant to arise; seen only in early post-seroconversion period; Elispot response <50 SFC/106PBMC. |
Variant ID. | 3370 |
---|---|
Epitope Seq. | SLFNTVATL |
Variant Seq. | SLFSTVATL |
Mutations | N/S |
Epitope Location | N4S |
HXB2 Location | N80S |
Mutation Type | OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | Third variant to arise; seen only in early post-seroconversion period; zero Elispot response. |
Variant ID. | 3371 |
---|---|
Epitope Seq. | SLFNTVATL |
Variant Seq. | SLFNTIATL |
Mutations | V/I |
Epitope Location | V6I |
HXB2 Location | V82I |
Mutation Type | SF: susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | Fourth variant to arise; seen only in late post-seroconversion period; Elispot response <100 SFC/106PBMC. |
Variant ID. | 3372 |
---|---|
Epitope Seq. | SLFNTVATL |
Variant Seq. | SLYNTVATL |
Mutations | F/Y |
Epitope Location | F3Y |
HXB2 Location | F79Y |
Mutation Type | SF: susceptible form |
Epitope Subtype | B |
Variant Subtype | B |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | Fifth variant to arise; seen only in late post-seroconversion period; positive Elispot response <50 SFC/106PBMC. |
Melhem2014 Nada M Melhem, Kellie N. Smith, Xiao-Li Huang, Bonnie A Colleton, Weimin Jiang, Robbie B. Mailliard, James I. Mullins, and Charles R. Rinaldo. The Impact of Viral Evolution and Frequency of Variant Epitopes on Primary and Memory Human Immunodeficiency Virus Type 1-Specific CD8+ T Cell Responses. Virology, 450-451:34-48, Feb 2014. PubMed ID: 24503065. Show all entries for this paper.
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